Dormizol

Dormizol

midazolam

Manufacturer:

Harson

Distributor:

Phil Pharmawealth
Concise Prescribing Info
Contents
Midazolam
Indications/Uses
Sedation in minor surgical or investigative procedures & in intensive care, for premed & induction of general anesth. Hypotonic in the short-term management of insomnia.
Dosage/Direction for Use
Individualized dose. Dental & minor surgery 2.5-7.5 mg (about 70 mcg/kg) IV. Initial dose: 2 mg over 30 sec w/ further incremental doses of 0.5-1 mg at 2-min intervals. Induction of anesth Premedicated patient 200 mcg/kg slow IV. Patient who did not received a premedicant 300 mcg/kg. Childn >7 yr 150 mcg/kg. ICU patient who require continuous sedation Initial loading dose: 30-300 mcg/kg IV infusion over 5 min. Maintenance dose: 20-200 mcg/kg/hr. Patient w/ hypovolemia, vasoconstriction, hypothermia Loading dose reduced or omitted & maintenance dose reduced. Sedation may also be achieved w/ repeated doses of 1-2 mg intermittent IV bolus inj. Premedicant Given IM about 30-60 min before surgery. Usual dose: 5 mg. Dose range: 70-100 mcg/kg.
Contraindications
Hypersensitivity to benzodiazepines. Myasthenia gravis, shock or coma, acute alcoholic intoxication w/ depression of vital signs, acute narrow-angle glaucoma.
Special Precautions
Should be administered slowly & in supine position. Monitor vital signs especially cardiorespiratory functions. Elderly, debilitated or very ill patients, high-risk surgical patients & those w/ significant hepatic impairment, chronic renal insufficiency, limited pulmonary reserve. Dependence. Avoid abrupt w/drawal. ICU patients receiving IV infusion for prolonged sedation. Pregnancy. Neonates & critically ill childn <3 yr.
Adverse Reactions
Resp depression, hypotension or cardiac arrest, death. Pain, tenderness & thrombophlebitis. Hiccups. May affect mental functions.
Drug Interactions
Enhanced sedation or resp & CV depression w/ alcohol, antidepressants, antihistamines, antipsychotics, general anesth, other hypnotics or sedatives & opioid analgesics. Shorten induction time w/ aspirin. Additive sedative effect, severe resp depression & reduced clearance w/ fentanyl; sudden hypotension w/ fentanyl or sulfentanil. Increased Cmax w/ erythromycin. Significant rise in steady-state blood conc w/ ciprofloxacin. Decreased t½ w/ rifampicin. Increased intensity & duration of action w/ ketoconazole & itraconazole. HIV-PIs. Doubled Cmax & half-life w/ diltiazem or verapamil. Cardioresp collapse & hypersalivation w/ clozapine. Reduced clearance w/ cimetidine. Enhanced sedative effect w/ cisapride. Marked reduction of halothane conc. Synergistic effect w/ thiopental, methohexital & propofol. Effects antagonized by flumazenil.
MIMS Class
Hypnotics & Sedatives
ATC Classification
N05CD08 - midazolam ; Belongs to the class of benzodiazepine derivatives. Used as hypnotics and sedatives.
Presentation/Packing
Form
Dormizol soln for inj 5 mg/mL
Packing/Price
1 mL x 10 × 1's;3 mL x 10 × 1's
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