Enhanced sedation or resp & CV depression w/ alcohol, antidepressants, antihistamines, antipsychotics, general anesth, other hypnotics or sedatives & opioid analgesics. Shorten induction time w/ aspirin. Additive sedative effect, severe resp depression & reduced clearance w/ fentanyl; sudden hypotension w/ fentanyl or sulfentanil. Increased Cmax
w/ erythromycin. Significant rise in steady-state blood conc w/ ciprofloxacin. Decreased t½
w/ rifampicin. Increased intensity & duration of action w/ ketoconazole & itraconazole. HIV-PIs. Doubled Cmax
& half-life w/ diltiazem or verapamil. Cardioresp collapse & hypersalivation w/ clozapine. Reduced clearance w/ cimetidine. Enhanced sedative effect w/ cisapride. Marked reduction of halothane conc. Synergistic effect w/ thiopental, methohexital & propofol. Effects antagonized by flumazenil.