Each capsule contains: Doxycycline (as Hydrochloride) 100 mg.
Pharmacologic Classification: Tetracycline Antibiotic.
Mechanism of Action: Doxycycline is taken up into sensitive bacterial cells by an Active transport process. Once within the cell they bind reversibly to the 30s subunit of the ribosome, preventing the binding of aminoacyl transfer RNA and inhibiting protein synthesis and hence cell growth. Although they inhibit protein synthesis in Mammalian cells, they are not actively taken up, permitting selective effects on the infecting organism.
Bioavailability and Pharmacokinetics: Doxycycline hydrochloride is readily and almost completely absorbed from the gastro-intestinal tract and absorption is not significantly affected by the presence of food in the stomach or duodenum. Mean peak plasma concentrations 2.6 μg per mL have been reported 2 hours after a 200 mg dose by mouth, falling to 1.45 μg per mL at 24 hours.
From 80 to 95% of doxycycline in the circulation is reported to be bound to plasma. Proteins its biological half-life varies from about 15 to 25 hours. Doxycycline is more lipid-soluble than tetracycline. It is widely distributed in body tissues and fluids.
In patients with normal renal function about 40% of a dose is slowly excreted in the urine although more is excreted by this route if urine is made alkaline. However, the majority of a dose of doxycycline is excreted in the feces following chelation in the intestines.
For the treatment of respiratory infections, ENT infections, genitourinary tract infections, skin and soft tissue infections and a wide variety of infections caused by gram-positive and gram-negative bacteria.
Usual adult dose: 200 mg on first day in single or divided doses of 100 mg every 12 hours; then 100 mg/day thereafter.
Should not be used in the latter half of pregnancy. Not recommended for children below 12 years as it causes tooth discoloration. Hypersensitivity to tetracyclines.
Should not be used in the latter half of pregnancy.
Gastrointestinal irritation, phototoxicity, hepatic toxicity, renal toxicity and yellow discoloration of the teeth.
Interferes with bacterial action of penicillins. Concomitant administration with antacids. Concomitant administration with Ferrous preparation may result in reduced absorption.
Protect from light. Store at temperature not exceeding 30°C.
J01AA02 - doxycycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.