Concise Prescribing Info
Doxycycline hyclate
STD; UTI; resp tract infections, GI infections; systemic infections; infections caused by E. coli, Enterobacter aerogenes, Shigella spp & Acinetobacter spp. Uncomplicated gonorrhea, syphilis, yaws, listeriosis, anthrax, Vincent's infection, actinomycosis infections caused by Clostridium spp. Adjunctive therapy in acute intestinal amebiasis, severe acne, refractory periodontitis & periodontal abscess. Prophylaxis of malaria.
Dosage/Direction for Use
Adult 200 mg on 1st day (100 mg every 12 hr) followed by maintenance dose of 100 mg/day once daily. Management of more severe infections (chronic UTI) 100 mg every 12 hr. STD (chlamydial cervicitis) 100 mg every 12 hr for 7 days. Pelvic inflammatory disease in ambulatory patient Cefoxitin 2 g IM or oral amoxicillin 3 g or oral ampicillin 3.5 mg or aqueous procaine penicillin G IM 4.8 MIU at 2 sites (accompanied by oral probenecid 1 g, followed by oral doxycycline 100 mg daily), or ceftriaxone 250 mg IM in 10-14 days. Early syphilis for non-pregnant patient allergic to penicillin 100 mg every 12 hr for 14 days. Syphilis of >1 yr duration in patient allergic to penicillin 100 mg every 12 hr for 4 wk. Uncomplicated gonococcal infections 100 mg every 12 hr or 300 mg stat followed in 1 hr by second 300 mg. Uncomplicated urethral, endocervical or rectal infection 100 mg every 12 hr for 7 days. Non-gonococcal urethritis 100 mg every 12 hr for 7 days. Acute epididymo-orchitis 100 mg every 12 hr for  at least 10 days. Acne vulgaris 100 mg once daily for 12 wk. Prophylaxis of traveller's diarrhea 200 mg on the 1st day of travel (as single dose or 100 mg every 12 hr) followed by 100 mg daily throughout stay in the area. Cholera 300 mg as single dose (treatment & prophylaxis). Leptospirosis Treatment: 100 mg every 12 hr for 7 days; prophylaxis: 200 mg on wkly basis throughout stay in the area & 200 mg upon completion of the trip. Tick & louse-borne relapsing fevers & louse-borne typhus Single dose of 100 or 200 mg depending on severity. Prophylaxis of scrub typhus 200 mg as single dose. Chloroquine-resistant falciparum malaria 200 mg daily for at least 7 days. Prophylaxis of malaria 100 mg daily. Start prophylaxis 1-2 days before travel to malarious areas. Continue daily during travel in these areas & 4 wk after leaving said areas. Refractory periodontitis in adults & periodontal abscess (if allergic to β-lactam) 100 mg every 12 hr for 7 days.
Should be taken with food: Take w/ meals to avoid GI irritation. Drink plenty of fluids to reduce risk of esophageal irritation & ulceration.
Hypersensitivity to tetracyclines.
Special Precautions
Drink plenty of fluids to reduce risk of esophageal irritation & ulceration. Reduced absorption w/ food that contain Ca. Avoid excessive sunlight or artificial UV light. Discontinue if phototoxicity occurs. Chronic use increases incidence of vag candidiasis. Benign intracranial HTN in adults. Bulging fontanels in infants. Discontinue if superinfection occurs. Perform lab evaluation in organ systems including hematopoietic, renal & hepatic in long-term therapy. Fanconi-like syndrome. Pregnancy & lactation. Childn <8 yr.
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis & inflammatory lesions (w/ monilial overgrowth) in the anogenital region. Maculopapular & erythematous rashes. Rise in BUN. Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis & exacerbation of SLE. Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia. Bulging fontanels in infants & intracranial HTN in adults.
Drug Interactions
Anticoagulants; penicillins. Decreased t½ w/ barbiturates, carbamazepine & phenytoin. Fatal renal toxicity w/ methoxyflurane. May render OCs less effective. Bismuth subsalicylate, antacids containing Al, Ca or Mg & Fe-containing prep may impair absorption of tetracyclines.
MIMS Class
ATC Classification
J01AA02 - doxycycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
Doxin cap 100 mg
50's (P93.56/cap, P4,678/pack)
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