Xanthine half-life may be increased and clearance decreased in patients with liver disease, congestive heart failure, chronic obstructive lung disease or concomitant infections. In these cases, the dose of doxofylline may be reduced.
Use with caution in patients with following conditions: Elderly; Hyperthyroidism; Hypoxemia; Peptic ulcer; Renal or hepatic disease; Cardiovascular disorders including cardiac arrhythmias, angina pectoris, acute myocardial injury, hypertension, or congestive heart failure.
Use in Elderly: Doxofylline should be administered cautiously to elderly patients. Dosage may be reduced and careful monitoring of doxofylline plasma concentrations may be required to avoid severe toxicity.
Use in Children: Doxofylline should be administered cautiously to young children.