High doses usually result to watery stools (diarrhoea), abdominal cramps and a clinically significant loss of fluid, potassium, and other electrolytes.
Bisacodyl (Dulcolax), as with other laxatives, when taken in chronic overdose may cause chronic diarrhoea, abdominal pain, hypokalaemia, secondary hyperaldosteronism, and renal calculi.
Renal tubular damage, metabolic alkalosis, and muscle weakness secondary to hypokalaemia have also been described in association with chronic laxative abuse.
After ingestion of oral forms of Bisacodyl (Dulcolax), absorption can be minimized or prevented by inducing vomiting or gastric lavage. Replacement of fluids and correction of electrolyte imbalance may be required. This is especially important in the elderly and the young.
Administration of antispasmodics may be of value.