Clinical experience of overdose is limited. Single IV doses of up to 200 mg parecoxib (Dynastat) have been administered to healthy subjects without clinically significant adverse effects. Parecoxib (Dynastat) doses of 50 mg IV twice daily (100 mg/day) for 7 days did not result in any signs of toxicity.
In case of suspected overdose, appropriate supportive medical care should be provided. Dialysis is unlikely to be an efficient method of drug removal, because of high protein binding of the drug.