Edoxaban - oral

Patient Medicine Information
Why do I need this medicine?
Edoxaban is used to prevent and reduce the risk of strokes in people with irregular heartbeats and those who have a high risk of getting them. It may also be used to treat blood clot in the veins of your leg or lungs and prevents it from re-occurring.
How do I take this medicine?
Take Edoxaban exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

Edoxaban must be taken regularly for it to be effective. Continue taking this medicine even when you feel better/well. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • active bleeding
  • uncontrolled high blood pressure
  • other diseases or conditions that may increase the risk of bleeding e.g. history of stomach ulcers, liver diseases, recent brain and spinal injury/surgery, tumours or blood vessel abnormalities
as Edoxaban may not be suitable for you.

Do not take Edoxaban if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. Edoxaban may cause harm to your unborn child. You must use proven birth control methods while taking this medicine.

Do not take Edoxaban with other blood-thinning medicines such as warfarin, or heparin except when changing your blood-thinning treatment, as it may increase the risk of stroke and bleeding respectively.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • bleeding problems
  • liver disease
  • kidney disease
  • heart disease
  • have mechanical (surgically implanted) heart valve
Be sure to check with your doctor or pharmacist before giving this medicine to an elderly.

If you are going for an operation or procedure involving a catheter or an injection into your spinal column (e.g. spinal or epidural anaesthesia), including surgery or dental work, inform your doctor that you are taking Edoxaban.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • You may need to have regular blood tests, liver and kidney function tests. Your doctor will advise you how often you need to have them.
  • You may also need to be closely monitored for any signs of bleeding.
What side effects could I experience?
Edoxaban may cause bleeding in your eyes, nose, gums, stomach, bowel and urine.

Other side effects include any of the following: headache, dizziness, nausea, stomach pain, rash, itching, urticaria.

Alert your doctor if you get any unusual bruising (large bruises or several bruises especially if they appear by themselves or if they cover a large area) or bleeding that takes long time to stop (e.g. too much bleeding when you floss or brush your teeth). Alert your doctor if you notice blood in your urine, bowel movements or if you get a nose bleed.

Some side effects may need immediate medical help. Alert you doctor quickly if you experience excessive or prolonged bleeding with leg weakness or numbness, and bladder/bowel dysfunction. This could be signs of long term paralysis.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Edoxaban with other blood-thinning medicines such as warfarin, or heparin except when changing your blood-thinning treatment, as it may increase the risk of stroke and bleeding respectively.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • ciclosporin (medicine used in organ transplant or certain immune disorders)
  • medicines to treat fungal infection e.g. ketoconazole, itraconazole
  • antibiotics e.g. erythromycin, azithromycin, clarithromycin
  • medicines for heart disease e.g. dronedarone, amiodarone, verapamil, quinidine
  • medicine for pain and inflammation e.g. naproxen
  • medicines for epilepsy (fits or seizures) e.g. phenytoin, carbamazepine, phenobarbital
This list does not include all medicines that may interact with Edoxaban.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.

Avoid St. John’s wort.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on edoxaban - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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