Concise Prescribing Info
Cefuroxime Na
Susceptible infections including bone & joint infections, bronchitis & other lower resp tract infections, gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin & soft tissue infections & UTI. Prophylaxis of surgical infections.
Dosage/Direction for Use
Tab Adult Uncomplicated UTI 125 mg bid. Resp tract infection 250-500 mg bid. Childn >2 yr Otitis media 250 mg bid or 15 mg/kg bid. Max: 500 mg daily. Childn >3 mth 125 mg bid or 10 mg/kg bid. Max: 250 mg daily. Inj Adult 750 mg IM/IV tid. Severe cases Up to 1.5 g IM tid. Total daily dose: 3-6 g IM/IV in 4 divided doses. Infant & childn 30-100 mg/kg/day in 3 or 4 divided doses. Neonate 30-100 mg/kg/day IM/IV in 3 or 4 divided doses. Gonorrhea 1.5 g IM once or equally divided between 2 gluteal inj sites. Meningitis Adult 3 g IV tid. Infant & childn 200-240 mg IV in 3 or 4 divided doses daily, may be reduced to 100 mg/kg/day after 3 days or when clinically improves. Neonate Initially 100 mg/kg/day IV, may be reduced to 50 mg/kg/day. Post-op prophylaxis of infections: Abdominal, pelvic & orthopedic operations 1.5 g IV w/ anesth induction, may be supplemented w/ two 750 mg IM doses after 8-16 hr. Cardiac, pulmonary, esophageal & vascular operations 1.5 g IV w/ anesth induction followed w/ 750 mg IM tid for a further 24 or 48 hr. Total joint replacement 1.5 g powd mixed w/ methyl methacrylate cement polymer before adding liqd monomer.
Should be taken with food: Take w/ meals for optimum absorption.
Inj: History of shock to cefuroxime Na or axetil.
Special Precautions
Tab: Porphyria. Inj: Hypersensitivity to penicillins. History or family history of allergic symptoms eg, bronchial asthma, exanthema, urticaria. Severe renal disorder. Monitor for vit K deficiency in patients w/ poor oral ingestion or TPN patients w/ poor general conditions. Perform skin reaction test before & lab tests at regular intervals during treatment. Discontinue use in case of shock & if Stevens-Johnson syndrome, erythema multiforme, Lyell syndrome or anaphylactic reactions occur. Slight or severe auditory dysfunction in minor childn treated w/ meningitis. Monitor renal & hepatic function. False +ve results w/ urine glucose test using Benedict's & Fehling's reagent & Clinitest; direct Coombs' test. Women of childbearing potential. Pregnancy & lactation. Neonates ≤1 wk.
Adverse Reactions
Diarrhea, nausea. Tab: Vomiting. Inj: Hypersensitivity reactions. Occasionally, SGOT, SGPT & alkaline phosphatase elevations.
Drug Interactions
Inj: Worsened renal insufficiency w/ diuretics (eg, furosemide) & aminoglycosides.
MIMS Class
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Elixime powd for inj 750 mg
(vial) 10 mL x 10 × 1's (P325/vial)
Elixime tab 500 mg
20's (P1,730/box)
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