As shock may rarely occur, cautious monitoring is required, and in case that unpleasantness, stridor, dizziness, tenesmus, tinnitus, perspiration, etc. occur, administration should be discontinued and appropriate treatment should be taken.
In case exanthema, urticaria, erythema, flare, pruritus, shivering, fever, allergic dermatitis, edema, erythema multiforme, anaphylactic or anaphylactic-like reaction occur, further administration should be discontinued and appropriate measures taken.
Rarely severe enterocolitis with hemafecia such as pseudomembranous enterocolitis may occur. If abdominal pain and frequent diarrhea occur, appropriate measure such as immediate discontinuation of ceftriaxone should be taken. Also occasionally nausea, vomiting, loose stools, diarrhea, or rarely abdominal pain, anorexia, etc. may occur. And pancreatitis may occur, in this case, most of the patients have the risk factor occurring cholestatic or biliary sludge.
Since interstitial pneumonia, PIR syndrome, etc. accompanied with fever, cough, dyspnea, abnormal chest X-ray, eosinophilia, etc. may rarely occur with other cephems, in case that such symptoms occur, further administration should be discontinued and appropriate measures such as administration of corticosteroids, etc. should be taken.
Occasionally granulocytopenia, eosinophilia, thrombocytosis, leukopenia, rarely anemia, hemolytic anemia, thrombocytopenia, prothrombin abnormality may occur.
Central Nervous System:
Occasionally headache, dizziness, and rarely ataxia, dysaesthesia may occur.
Rarely, Steven-Johnson's syndrome or toxic epidermal necrolysis may occur.
In rare cases, increase of AST, ALT, and ALP, the symptom cause by precipitation of ceftriaxone-calcium in gallbladder may occur. Rarely increase of bilirubin, -GTP may occur.
Rare cases of severe renal disorder including acute kidney failure have been reported, if this occurs, renal activity should be monitored regularly. If any symptoms occur the administration should be discontinued and/or appropriate therapy should be instituted. Also diabetic hematuria, oliguria, may occur. Very rarely, precipitations in renal ureterolith in children over 3 years of age have been reported. This case happens for patients exceeding daily dosage of 10 g associated with the risk of dipsotherapy or clinotherapy. The precipitation in renal can continue to the renal disorder as syndromic or non-syndromic, but it can recover when the administration is discontinued.
Rarely stomatitis, candidiasis may occur.
Rarely vitamin K deficiencies such as hypoprothrombinemia or bleeding tendencies or vitamin B group deficiencies such as glossitis, anorexia, or neuritis may occur.
Edema, premature ventricular contraction, increasing of blood creatinine, mycosis of genitalia, sweat, flush, palpitation, epistaxis, etc. may occur.