Encifer

Encifer

iron sucrose

Manufacturer:

Emcure Pharma

Distributor:

Macropharma Corp
Concise Prescribing Info
Contents
Fe sucrose
Indications/Uses
Treatment of Fe deficiency anemia in the following patients: Hemodialysis dependent chronic kidney disease (HDD-CKD) receiving an erythropoietin; peritoneal dialysis dependent chronic kidney disease (PDD-CKD) receiving an erythropoietin; non-dialysis dependent chronic kidney disease (NDD-CKD) receiving an erythropoietin or not; during pregnancy & post-partum.
Dosage/Direction for Use
HDD-CKD 100 mg (5 mL) 1-3 times/wk by undiluted slow IV inj into the dialysis line over 2-5 min or by IV infusion (into the dialysis line for hemodialysis patients) as every 5 mL is diluted in a max of 100 mL of 0.9% NaCl at a rate of 100 mg Fe over a period of at least 15 min. NDD-CKD 200 mg by slow IV inj undiluted over 2-5 min on 5 different occasions w/in 14 day period. PDD-CKD 1,000 mg by IV infusion in 3 divided doses during a 28 day period: 2 infusions of 300 mg over 1.5 hr 14 days apart, followed by one 400 mg infusion over 2.5 hr 14 days later. Anemia during pregnancy & post partum 100-200 mg as a single dose repeated 3 times/wk by slow IV inj at the rate of 1 mL/min (20 mg Fe) not exceeding 100 mg Fe/inj or by IV infusion every 2.5 mL diluted in a max of 100 mL of 0.9% NaCl at a rate of 100 mg/15 min.
Contraindications
Hypersensitivity. Patients w/ evidence of Fe overload & anemia not caused by Fe deficiency.
Special Precautions
W/hold therapy in the presence of tissue Fe overload. Transferrin saturation values increase rapidly after administration. Hypotension in chronic disease patients. Periodic monitoring of hematologic & hematinic parameters. Pregnancy & lactation. Childn. Elderly.
Adverse Reactions
Hypotension, chest pain, HTN, hypervolemia, CHF, cramps, musculoskeletal pain, diarrhea, nausea, vomiting, abdominal pain, elevated liver enzymes, skin irritation, pruritus, application site reaction, dizziness, dyspnea, pneumonia, cough, headache, fever, asthenia, malaise.
Drug Interactions
Reduced absorption of oral Fe prep.
MIMS Class
Vitamins & Minerals (Pre & Post Natal) / Antianemics
ATC Classification
B03AC - Iron, parenteral preparations ; Used in the treatment of anemia
Presentation/Packing
Form
Encifer soln for inj 20 mg/mL
Packing/Price
5 mL x 5 × 1's
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