amoxicillin + clavulanic acid




Concise Prescribing Info
Co-amoxiclav (amoxicillin & K clavulanate). Per FC tab Amoxicillin 500 mg, K clavulanate 125 mg
Lower resp tract infection, otitis media, sinusitis, skin & skin structure infection & UTI.
Dosage/Direction for Use
Adult 625 mg every 12 hr or 375 mg every 8 hr. Severe infections & resp tract infections 1,000 mg every 12 hr or 625 mg every 8 hr. Childn weighing ≥40 kg Adult dose. Severely impaired patient w/ GFR 10-30 mL/min 625 mg or 375 mg or every 12 hr, <10 mL/min 625 mg or 375 mg every 24 hr.
May be taken with or without food: Preferably taken at the start of meals for better absorption & to reduce GI discomfort.
Hypersensitivity to co-amoxiclav, β-lactams eg, penicillins or cephalosporins. History of co-amoxiclav-associated jaundice/hepatic dysfunction.
Special Precautions
Evidence of hepatic dysfunction; monitor hepatic function at regular intervals. Concomitant use w/ drugs that delay peristalsis eg, opiates & diphenoxylate w/ atropine. Require fluids, electrolytes & protein replacement therapy. Pregnancy & lactation.
Adverse Reactions
Gastritis, stomatitis, glossitis, black hairy tongue, indigestions, nausea, vomiting, diarrhea, enterocolitis, pseudomembranous colitis, candidiasis; skin rashes, urticaria; transient hepatitis, cholestatic jaundice; anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, agranulocytosis.
Drug Interactions
Avoid concomitant use w/ alcohol. Amoxicillin: Decreased plasma conc of total conjugated estriol, cestadiol. Increased & prolonged blood levels w/ probenecid. May increase incidence of rashes w/ allopurinol.
MIMS Class
ATC Classification
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Endclav-625 FC tab
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