Adults: The usual adult dose is 625 mg tablets of co-amoxiclav every 12 hours or one 375 mg tablet of co-amoxiclav every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 1000 mg tablet of co-amoxiclav every 12 hours or one 625 mg tablet of co-amoxiclav every 8 hours. Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe.
Severely impaired patients with a glomerular filtration rate of <30 mL/min should not receive the 1000 mg tablet. Severely impaired patients with a glomerular filtration rate of 10 to 30 mL/min should receive 625 mg or 375 mg or every 12 hours, depending on the severity of the infection. Patients with a less than 10 mL/min glomerular filtration rate should receive 625 or 375 every 24 hours, depending on severity of the infection.
Hepatically impaired patients should be dosed with caution and hepatic function monitored at regular intervals.
Pediatric Patients: Pediatric patients weighing 40 kg or more should be dosed according to the adult recommendations. Due to the different amoxicillin to clavulanic acid ratios in the 375 mg tablet of co-amoxiclav versus 250 mg chewable tablet of co-amoxiclav should not be used until the pediatric patients weighs at least 40 kg or more.
Administration: Co-amoxiclav may be taken without regard to meals, however, absorption of Clavulanate potassium is enhanced when co-amoxiclav is administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, co-amoxiclav should be taken all the start of a meal or as directed by the physician.