Enzalutamide - oral

Patient Medicine Information
Why do I need this medicine?
Enzalutamide is used to treat men with prostate cancer that has spread to other parts of the body or which no longer responds to medical or surgical treatment.
How do I take this medicine?
Take Enzalutamide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

Swallow the capsule whole. Do not chew, dissolve or open the capsule.

The dose of Enzalutamide will be decided by your doctor. Your doctor will advise you on the course of your treatment depending on your condition, effectiveness of the therapy, and your tolerability to this medicine.

This medicine must be taken regularly for it to be effective. Continue taking Enzalutamide even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Enzalutamide is not for use in women. Do not take Enzalutamide if you are pregnant or breastfeeding.

Enzalutamide may possibly affect male fertility. You must use proven birth control methods while taking this medicine. Adequate contraceptive methods must be used during therapy and for a certain period of time after stopping the treatment. You may wish to discuss birth control methods with your doctor.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • history of seizures or of high risk for seizures (e.g. brain injury, head trauma, brain tumour, cancer which has spread to the brain, stroke, consume large amounts of alcohol or if you are a frequent drinker, or if you are taking medicines that may cause seizures)
  • heart disease (e.g. heart rhythm disorder)
  • high blood pressure
  • severe kidney disease
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • You may need to have routine tests (e.g. complete blood count, liver function test). Your doctor will advise you about how often you will need to have these tests.
  • Regular monitoring of blood pressure, signs and symptoms of seizures, infections, or toxicity may be needed while you are being treated with this medicine.
What side effects could I experience?
Enzalutamide may cause dizziness or seizures. If affected, do not drive, operate machinery, or take part in any activity in which you may be at risk of falling or getting injured (e.g. contact sports).

Other side effects include any of the following: headache, constipation, diarrhoea, decreased appetite, nausea, weakness, back pain, bone pain, joint pain, muscle pain, hot flush, swelling of the ankles, feet or hands, increase in blood pressure, forgetfulness, and reduced concentration.

This medicine will cause the level of your white blood cells to drop. White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience seizures, severe headache, confusion, or any change in your vision.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for epilepsy (fits or seizures) e.g. carbamazepine, phenobarbital, phenytoin
  • cholesterol-lowering medicines e.g. gemfibrozil
  • blood-thinning medicines e.g. warfarin
  • medicines for fungal infection e.g. itraconazole
  • medicines for abnormal heartbeat e.g. bosentan, quinidine
  • medicines for HIV infection e.g. efavirenz, etravirine
  • medicine to treat TB (infection known as tuberculosis) e.g. rifampicin
  • medicines for sleep disorder e.g. modafinil
  • medicines for mood disorder e.g. midazolam
  • medicines that reduce stomach acid production e.g. omeprazole
  • herbal supplement e.g. St. John’s Wort
This list does not include all medicines that may interact with Enzalutamide.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As this is a cancer medicine, always return any unused or expired medicine to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.
This information is independently developed by MIMS based on enzalutamide - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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