|
Indications and Dosage
Oral
Muscle spasms Adult: 50 mg tid, adjust dose based on age and symptoms.
|
|
Administration
Should be taken with food.
|
|
Contraindications
Lactation.
|
|
Special Precautions
Hepatic impairment. Pregnancy.
|
|
Adverse Reactions
Significant: Shock, anaphylaxis reactions (e.g. redness, itching, urticaria, oedema, dypnoea), Stevens-Johnson syndrome and toxic epidermal necrolysis.
Blood and lymphatic system disorders: Anaemia. Cardiac disorders: Palpitations. Gastrointestinal disorders: Nausea, vomiting, stomach discomfort, abdominal pain, diarrhoea, constipation, stomatitis, feeling of enlarged abdomen, hiccup. General disorders and admin site conditions: Weakness, fatigue, diaphoresis. Investigations: Elevated BUN. Metabolism and nutrition disorders: Anorexia, thirst. Musculoskeletal and connective tissue disorders: Stiffness, muscle hypotonia. Nervous system disorders: Headache, numbness of extremities, tremor, light-headedness, dizziness. Psychiatric disorders: Sleepiness, insomnia. Renal and urinary disorders: Proteinuria, urinary retention, urinary incontinence. Skin and subcutaneous tissue disorders: Rash, pruritus, erythema exudative multiforme. Vascular disorders: Hot flushes. |
|
Patient Counseling Information
This drug may cause weakness, light-headedness or sleepiness, if affected, do not drive or operate machinery.
|
|
Drug Interactions
Concomitant use of methocarbamol with tolperizone HCl may cause visual accommodation disturbance.
|
|
Action
Description: Eperisone is centrally-acting agent which relaxes skeletal muscles by inhibition of experimentally-induced muscle rigidity, suppression of spinal reflexes and reduction of muscle spindle sensitivity via γ-motor neurons. It also dilates vascular smooth muscles and augments blood flow.
Pharmacokinetics: Absorption: Time to peak plasma concentration: 1.6-1.9 hours. Distribution: Enters breast milk. Excretion: Half-life elimination: 1.6-1.8 hours. |
|
Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 3236, Eperisone. https://pubchem.ncbi.nlm.nih.gov/compound/Eperisone. Accessed May 26, 2022. |
|
Storage
Store below 30°C.
|
|
MIMS Class
|
|
ATC Classification
M03BX09 - eperisone ; Belongs to the class of other centrally-acting muscle relaxants.
|
|
References
Buckingham R (ed). Eperisone Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 31/01/2019. Myonal 50 mg Tablet (HI-Eisai Pharmaceutical, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 31/01/2019. Myonal 50 mg Tablets (Esai [Malaysia] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 31/01/2019.
|
Sign Out
