Eperisone: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Philippines prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Myotonic symptoms, Spastic paralysis

Adult: Usual dose: 50 mg tid; may be adjusted based on patient's age and symptoms. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

Administration

Should be taken with food.

Contraindications

Myasthenia gravis. Lactation. Contraindications may vary among individual products (refer to specific product labelling).

Special Precautions

Hepatic impairment. Elderly. Pregnancy.

Adverse Reactions

Significant: Shock and anaphylactoid reactions (e.g. urticaria, pruritus, oedema of the face or other parts, dyspnoea), Stevens-Johnson syndrome, toxic epidermal necrolysis; weakness, dizziness, drowsiness.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, stomach discomfort, abdominal pain.
General disorders and administration site conditions: Fatigue.
Metabolism and nutrition disorders: Anorexia, increased thirst.
Nervous system disorders: Headache, numbness of the extremities.
Psychiatric disorders: Insomnia.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Hot flushes.

Patient Counseling Information

This drug may cause sleepiness, weakness, or lightheadedness, if affected, do not drive or operate machinery.

Drug Interactions

May increase the risk of adverse effects of methocarbamol.

Action

Description: Eperisone is a centrally acting skeletal muscle relaxant that decreases muscle spindle sensitivity through the inhibition of spontaneous discharge of γ-motor neurons. It also exhibits vasodilatory action through antagonism of Ca influx.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: 1.6-1.9 hours.
Excretion: Elimination half-life: 1.6-1.8 hours.

Chemical Structure

Storage

Store below 30°C. Protect from light and moisture.

MIMS Class

Muscle Relaxants

ATC Classification

M03BX09 - eperisone ; Belongs to the class of other centrally-acting muscle relaxants.

References

Anon. Eperisone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/03/2022.

Buckingham R (ed). Eperisone Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2022.

Myelax 50 mg Tablet (The Cathay Drug Co., Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 08/03/2022.

Myonal 50 mg Tablet (HI-Eisai Pharmaceutical, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 08/03/2022.

Myonal 50 mg Tablets (Esai [Malaysia] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 08/03/2022.

Perispa 50 mg Sugar Coated Tablet (Wert Philippines, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 28/04/2022.

Disclaimer: This information is independently developed by MIMS based on Eperisone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by MIMS.com