Generic Medicine Info
Indications and Dosage
Muscle spasms
Adult: 50 mg tid, adjust dose based on age and symptoms.
Should be taken with food.
Special Precautions
Hepatic impairment. Pregnancy.
Adverse Reactions
Significant: Shock, anaphylaxis reactions (e.g. redness, itching, urticaria, oedema, dypnoea), Stevens-Johnson syndrome and toxic epidermal necrolysis.
Blood and lymphatic system disorders: Anaemia.
Cardiac disorders: Palpitations.
Gastrointestinal disorders: Nausea, vomiting, stomach discomfort, abdominal pain, diarrhoea, constipation, stomatitis, feeling of enlarged abdomen, hiccup.
General disorders and admin site conditions: Weakness, fatigue, diaphoresis.
Investigations: Elevated BUN.
Metabolism and nutrition disorders: Anorexia, thirst.
Musculoskeletal and connective tissue disorders: Stiffness, muscle hypotonia.
Nervous system disorders: Headache, numbness of extremities, tremor, light-headedness, dizziness.
Psychiatric disorders: Sleepiness, insomnia.
Renal and urinary disorders: Proteinuria, urinary retention, urinary incontinence.
Skin and subcutaneous tissue disorders: Rash, pruritus, erythema exudative multiforme.
Vascular disorders: Hot flushes.
Patient Counseling Information
This drug may cause weakness, light-headedness or sleepiness, if affected, do not drive or operate machinery.
Drug Interactions
Concomitant use of methocarbamol with tolperizone HCl may cause visual accommodation disturbance.
Description: Eperisone is centrally-acting agent which relaxes skeletal muscles by inhibition of experimentally-induced muscle rigidity, suppression of spinal reflexes and reduction of muscle spindle sensitivity via γ-motor neurons. It also dilates vascular smooth muscles and augments blood flow.
Absorption: Time to peak plasma concentration: 1.6-1.9 hours.
Distribution: Enters breast milk.
Excretion: Half-life elimination: 1.6-1.8 hours.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 3236, Eperisone. https://pubchem.ncbi.nlm.nih.gov/compound/Eperisone. Accessed May 26, 2022.

Store below 30°C.
MIMS Class
Muscle Relaxants
ATC Classification
M03BX09 - eperisone ; Belongs to the class of other centrally-acting muscle relaxants.
Buckingham R (ed). Eperisone Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 31/01/2019.

Myonal 50 mg Tablet (HI-Eisai Pharmaceutical, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 31/01/2019.

Myonal 50 mg Tablets (Esai [Malaysia] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 31/01/2019.

Disclaimer: This information is independently developed by MIMS based on Eperisone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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