Epiven

Epiven

gabapentin

Manufacturer:

Prosweal Healthcare

Distributor:

Prosweal Healthcare
Concise Prescribing Info
Contents
Gabapentin
Indications/Uses
Partial seizures w/ or w/o secondary generalization, hemopathic pain. Adjunctive therapy in patients unresponsive to or intolerant of standard anticonvulsants.
Dosage/Direction for Use
Epilepsy Initially 300 mg on the 1st day of treatment, 300 mg bid on the 2nd day & 300 mg tid on the 3rd day. Thereafter, may increase dose in increments of 300 mg every 2-3 days until effective antiepileptic control is achieved which is usually w/in the range of 0.9-3.6 g daily. Max: 4.8 g daily in 3 equally divided doses. Max time interval between doses: 12 hr. Neuropathic pain Titrate dose similar to treatment of epilepsy to a max of 1.8 g daily in 3 divided doses. Childn ≥6 yr Adjunctive therapy in partial seizures Initially 10-15 mg/kg daily titrated over a period of 3 days. Effective dose: 25-35 mg/kg daily. Max: 50 mg/kg daily. Childn 2-12 yr Maintenance: 10-20 mg/kg tid (up to 900 mg daily for childn weighing ≤36 kg or 1.2 g daily for >36 kg). Older childn Adult dose. Max: 2.4 g daily. Patient w/ renal impairment: CrCl 50-79 mL/min 600-1,800 mg daily in 3 divided doses, 30-49 mL/min 300-900 mg daily in 3 divided doses, 15-29 mL/min 300 mg on alternate days to 600 mg daily in 3 divided doses, <15 mL/min 300 mg on alternate days to 300 mg daily in 3 divided doses. Patient undergoing hemodialysis Loading dose: 300-400 mg, followed by 200-300 mg after each 4-hr hemodialysis.
Administration
May be taken with or without food: Swallow whole w/ sufficient fluid.
Contraindications
Special Precautions
Patients w/ renal impairment & those undergoing hemodialysis. May cause false +ve result w/ some urinary protein tests. Withdrawal of therapy. May affect ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Somnolence, dizziness, ataxia, fatigue; potentially, Stevens-Johnson syndrome. Confusion, depression, nervousness.
Drug Interactions
Reduced absorption from the GIT by antacids containing Al w/ Mg (take at least 2 hr after any antacid). Reduced clearance w/ morphine (monitor signs of CNS depression) & cimetidine.
MIMS Class
ATC Classification
N03AX12 - gabapentin ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Epiven cap 300 mg
Packing/Price
30's
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