Esofag

Esofag

esomeprazole

Manufacturer:

Micro Labs

Distributor:

Brown & Burk Phils
Concise Prescribing Info
Contents
Esomeprazole
Indications/Uses
PUD, GERD, Zollinger-Ellison syndrome, H. pylori eradication in combination w/ antibiotics.
Dosage/Direction for Use
Adult GERD 40 mg once daily for 4 wk. Additional 4 wk for patients whom esophagitis has not healed or w/ persistent symptoms. Long term management of patients w/ healed esophagitis to prevent relapse 20 mg once daily. Symptomatic treatment of GERD 20 mg once daily in patients w/o esophagitis. In combination w/ appropriate antibacterials for H. pylori eradication & healing of H. pylori associated w/ duodenal ulcer & prevention of relapse in patients w/ H. pylori associated ulcers Esomeprazole 20 mg + amoxicillin 1 g + clarithromycin 500 mg all bid for 7 days. Healing of gastric ulcer associated w/ NSAID therapy 20 mg once daily for 4-8 wk. Prevention of gastric & duodenal ulcers associated w/ NSAID therapy 20 mg once daily. Zollinger-Ellison syndrome Initially 40 mg bid. Doses >80 mg daily should be divided & given bid. Severe liver impairment Max: 20 mg.
Administration
Should be taken on an empty stomach: Take at least 1 hr before meals. Swallow whole, do not chew/crush.
Contraindications
Special Precautions
Long-term use. May lead to slightly increased risk of GI infections eg, salmonella & campylobacter. Concurrent use of other drugs (CYP3A4 eg, cisapride) in triple therapy for H. pylori eradication. May reduce absorption of vit B12 due to hypo- or achlorhydria. Hypomagnesemia. Risk of fracture. Sub-acute cutaneous lupus erythematosus. Co-administration w/ atazanavir & clopidogrel is not recommended. Pregnancy & lactation.
Adverse Reactions
Headache; abdominal pain, constipation, diarrhoea, flatulence, nausea/vomiting.
Drug Interactions
Increased gastric pH w/ PIs. Decreased serum levels w/ atazanavir; rifampicin, St. John's wort. May increase methotrexate levels. May increase serum levels of tacrolimus. May decrease clearance of diazepam. May increase plasma conc w/ diazepam, citalopram, imipramine, clomipramine, phenytoin. Increased AUC w/ voriconazole, cilostazol, cisapride. Cases of elevated INR w/ warfarin or other coumarin derivatives. May decrease exposure of clopidogrel.
ATC Classification
A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Form
Esofag EC tab 20 mg
Packing/Price
30's (P1,200/box)
Form
Esofag EC tab 40 mg
Packing/Price
30's (P1,800/box)
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