Getz Pharma


Getz Pharma
Concise Prescribing Info
Short-term treatment of GERD w/ erosive esophagitis in adults & ped 1 mth-17 yr, inclusively as alternative to oral therapy when oral esomeprazole is not possible or appropriate.
Dosage/Direction for Use
Adult 20 or 40 mg once daily by IV inj (no <3 min) or IV infusion (10-30 min) for 10 days. Childn 1-17 yr, ≥55 kg 20 mg infused over 10-30 min, <55 kg 10 mg infused over 10-30 min. Infant 1 mth to <1 yr 0.5 mg/kg infused over 10-30 min.
Hypersensitivity to esomeprazole or substituted benzimidazoles.
Special Precautions
Does not preclude presence of gastric malignancy. Atrophic gastritis; hypomagnesemia. Increased risk for osteoporosis-related fractures of the hip, wrist or spine. Monitor Mg levels prior to therapy periodically. Concomitant use w/ digoxin & diuretics. Pregnancy. Do not use during lactation.
Adverse Reactions
Headache, flatulence, nausea, abdominal pain, diarrhoea, dry mouth, dizziness, vertigo, constipation, inj site reaction, pruritus.
Drug Interactions
Increased INR & prothrombin time w/ warfarin. May potentially interfere w/ CYP2C19 & decrease clearance of diazepam. Double exposure w/ CYP2C19 & CYP3A4 inhibitor eg, voriconazole. May increase conc of cilostazol & decrease plasma conc of atazanavir. May interfere absorption of antiretroviral drugs, ketoconazole, Fe salts & digoxin. Decreased serum levels w/ atazanavir & nelfinavir. Possible toxicity w/ saquinavir or ritonavir.
ATC Classification
A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Esoget lyo powd for inj 40 mg
1's (P705/box)
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