Adverse effects is reported most frequently with esomeprazole have been headache, diarrhea, and skin rashes; they have sometimes been severe enough to require discontinuation of treatment. Other side effects include pruritus, dizziness, fatigue, constipation, nausea and vomiting, flatulence, abdominal pain, arthralgia and myalgia, urticartia and dry mouth, isolated cases of photosensitivity, bullous eruption, erythema multiforme, angioedema and anaphylaxis have been reported. Effects on the CNS include occasional insomnia, somnolence and vertigo; reversible confusional strains, agitation, depression and hallucinations have been occurred in severely ill patients. Raised liver enzymes and isolated cases of hepatitis, jaundice and hepatic encephalopathy have been reported. Other adverse effects reported rarely or in isolated cases include paraesthesia, blurred vision, alopacts, stomatitis, taste disturbance peripheral edema, hyponatremia, blood disorders (including agranulocytosis, leucopenia and thrombocytopenia) and interstitial nephritis.