Monitor BP, renal function, CV or resp status, signs of adrenal insufficiency.
Symptoms: Hypotension, resp depression, which may lead to arrest, disorientation, delayed awakening. Management: Supportive treatment. Admin of hydrocortisone (not ACTH) 50-100 mg may be required.
Increased hypnotic effect when used w/ neuroleptic drugs, opioids and sedatives. May enhance the effect of hypotensive drugs.
Enhanced hypnotic effect w/ alcohol.
Description: Etomidate, a carboxylated imidazole, is a sedative and hypnotic agent used for general anaesthesia. It enhances the activity of γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the CNS, by interacting w/ the GABAA receptor complex. Onset: 30-60 seconds. Duration: Dose dependent: 2-3 min (0.15 mg/kg/dose); 4-10 min (0.3 mg/kg/dose). Pharmacokinetics: Absorption: Time to peak plasma concentration: 7 min. Distribution: Rapidly distributed into CNS and other body tissues. Crosses placenta and enters breast milk. Volume of distribution: 2-4.5 L/kg. Plasma protein binding: Approx 76%. Metabolism: Rapidly metabolised in the liver and plasma. Excretion: Via urine, approx 75% (80% as metabolite, 2% as unchanged drug). Terminal elimination half-life: 2.6-3.5 hr.
N01AX07 - etomidate ; Belongs to the class of other general anesthetics.
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