Potential for gout flares, elevated liver enzymes & adverse CV events after initiation of therapy. Consider concomitant prophylaxis w/ NSAID or colchicine for gout flares. Monitor for rash, chest pain, shortness of breath or neurologic symptoms suggesting a stroke. Not recommended for the treatment of asymptomatic hyperuricemia; patients in whom the rate of urate formation is greatly increased (eg, malignant disease & its treatment, Lesch-Nyhan syndrome). Severe renal (CrCl <30 mL/min) & hepatic (Child-Pugh class C) impairment. Pregnancy & lactation.