Piroxicam (Feldene Flash) is generally well tolerated. Gastrointestinal symptoms are the most commonly encountered side effects but in most instances do not interfere with the course of therapy.
Objective evaluations of gastric mucosal appearances and intestinal blood loss show that 20 mg/day of piroxicam (Feldene Flash) administered either in single or divided daily doses is significantly less irritating to the gastrointestinal tract than acetylsalicylic acid.
Blood and Lymphatic System Disorders:
Anemia, aplastic anemia, eosinophilia, hemolytic anemia, leucopenia, thrombocytopenia.
Immune System Disorders:
Anaphylaxis, serum sickness.
Metabolism and Nutrition Disorders:
Anorexia, hyperglycemia, hypoglycemia, fluid retention.
Depression, dream abnormalities, hallucinations, insomnia, mental confusion, mood alterations, nervousness.
Nervous System Disorders:
Aseptic meningitis, dizziness, headache, paresthesia, somnolence, vertigo.
Blurred vision, eye irritations, swollen eyes.
Ear and Labyrinth Disorders:
Hearing impairment, tinnitus.
Respiratory, Thoracic and Mediastinal Disorders:
Bronchospasm, dyspnea, epistaxis.
Abdominal discomfort, abdominal pain, constipation, diarrhea, epigastric distress, flatulence, gastritis, gastrointestinal bleeding (including hematemesis and melena), indigestion, nausea, pancreatitis, perforation, stomatitis, ulceration, vomiting (see Gastrointestinal (GI) Effects under Precautions).
Fatal hepatitis, jaundice.
Reproductive System and Breast Disorders:
Female fertility decreased.
Skin and Subcutaneous Tissue Disorders:
Alopecia, angioedema, dermatitis exfoliative, erythema multiforme, non-thrombocytopenic purpura (Henoch-Schoenlein), onycholysis, photoallergic reactions, pruritus, skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's disease), urticaria, vesiculo bullous reactions (see Skin Reactions under Precautions).
Renal and Urinary Disorders:
Nephrotic syndrome, glomerulonephritis, interstitial nephritis; renal failure.
Edema (mainly of the ankle), malaise.
Positive ANA, reversible elevations of BUN and creatinine, decreases in hemoglobin and hematocrit unassociated with obvious gastro-intestinal bleeding, increased serum transaminase levels, weight decrease, weight increase.