The most frequently reported adverse events include abnormal elevation in serum transaminases (ALT and/or AST), epigastric distress, flatulence, abdominal pain, nausea, diarrhea, constipation, erythema, pruritus, urticaria, muscle pain and weakness, arthralgia, headache, dizziness, insomnia, decreased libido, hair loss, and weight loss.
Body as a whole:
Back pain, asthenia, flu syndrome, chest pain, malaise, accidental injury.
Thromboembolism (pulmonary embolism, deep vein thrombosis).
Dyspepsia, gastritis, vomiting, gastrointestinal disorder, pancreatitis.
Acute renal failure, impotence.
Hemic and Lymphatic:
Anemia, agranulocytosis, thrombocytopenia.
Cirrhosis, hepatitis, jaundice, development of gallstones, complications of cholelithiasis (e.g., cholecystitis, cholangitis, biliary colic).
Metabolic and Nutritional:
Elevations in the following: CPK, urea, plasma creatinine; Reductions in the following: plasma alkaline phosphatase, hematocrit, hemoglobin, leukocytes; severely depressed HDL-C levels.
Myositis, myalgia, arthralgia, muscular cramps and weakness, muscle spasm, rhabdomyolysis.
Respiratory disorder, rhinitis, pharyngitis, bronchitis, sinusitis, interstitial pneumopathies.
Skin and Appendages:
Hypersensitivity reactions, rash, photosensitivity reactions/cutaneous photosensitivity with erythema, vesiculation or nodulation on parts of the skin exposed to sunlight or artificial UV light (e.g., sun lamp), skin disorder, severe cutaneous reactions (e.g., erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), alopecia.