Fentyn

Fentyn

fentanyl

Manufacturer:

HEXAL

Distributor:

UNILAB, Inc
Concise Prescribing Info
Contents
Fentanyl
Indications/Uses
Severe chronic pain which can be adequately treated only w/ opioid analgesics.
Dosage/Direction for Use
Individualized dosage. Patient receiving opioid for the 1st time Initial dosage should not exceed 12.5-25 mcg/hr. Dose titration: 12.5 mcg/hr for 48-72 hr, may be increased after 3 days. Additional dose adjustment in 12.5-25 mcg/hr increments. Max: 300 mcg/hr.
Contraindications
Hypersensitivity. Acute or post-op pain, severe CNS impairment, severe resp depression.
Special Precautions
Resp depression; chronic obstructive or other pulmonary disease. Increased intracranial pressure, impaired consciousness or coma; brain tumors. Prior history of drug dependence/alcohol abuse. Bradyarrhythmias; hypotension, especially in patients w/ acute hypovolemia. Avoid exposing application site to direct external heat sources. Chronic constipation; discontinue if paralytic ileus is present or suspected. Myasthenia gravis. Concomitant use w/ SSRIs, SNRIs & MAOIs. Accidental exposure by patch transfer. May cause +ve reaction to anti-doping tests. May impair ability to drive or operate machinery. Hepatic & renal impairment. Pregnancy & lactation. Child <2 yr. Elderly.
Adverse Reactions
Somnolence, dizziness, headache; nausea, vomiting, constipation. Hypersensitivity; anorexia; insomnia, depression, anxiety, confusional state, hallucination; tremor, paresthesia; vertigo; palpitations, tachycardia; HTN; dyspnea; diarrhea, dry mouth, abdominal pain, upper abdominal pain, dyspepsia; hyperhidrosis, pruritus, rash, erythema; muscle spasms; urinary retention; fatigue, peripheral edema, asthenia, malaise, feeling cold. Resp depression.
Drug Interactions
May produce additive depressant effects w/ other CNS depressants, including opioids, sedatives, hypnotics, general anesth, phenothiazines, tranquilizers, skeletal muscle relaxants, sedating antihistamines & alcoholic beverages. Increased plasma conc w/ CYP3A4 inhibitors (eg, ritonavir, ketoconazole, itraconazole, fluconazole, voriconazole, troleandomycin, clarithromycin, nelfinavir, nefazodone, verapamil, diltiazem, & amiodarone). Decreased plasma conc w/ CYP3A4 inducers (eg, rifampicin, carbamazepine, phenobarb, phenytoin). Potentiate opiate or serotonergic effects w/ MAOIs. May increase risk of serotonin syndrome, potentially life-threatening condition w/ serotonergic agent eg, SSRIs or MAOIs. Partially antagonize analgesic effect w/ buprenorphine, nalbuphine or pentazocine.
MIMS Class
ATC Classification
N02AB03 - fentanyl ; Belongs to the class of phenylpiperidine derivative opioids. Used to relieve pain.
Presentation/Packing
Form
Fentyn transdermal patch 50 mcg/hr
Packing/Price
5's
Form
Fentyn transdermal patch 25 mcg/hr
Packing/Price
5's
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