Fexofenadine


Generic Medicine Info
Indications and Dosage
Oral
Seasonal allergic rhinitis
Adult: 120 mg once daily. Alternatively, 60 mg bid or 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: 2-11 years 30 mg bid; ≥12 years Same as adult dose. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).

Oral
Chronic idiopathic urticaria
Adult: 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: 6 months-<2 years 15 mg bid; 2-11 years 30 mg bid; ≥12 years 60 mg bid or 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Administration
Should be taken on an empty stomach. Do not take w/ fruit juice.
Special Precautions
Patient with current or history of CV disease. Renal and hepatic impairment. Children. Pregnancy and lactation.
Adverse Reactions
Cardiac disorders: Palpitations, tachycardia.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, dyspepsia.
General disorders and administration site conditions: Fatigue.
Immune system disorders: Hypersensitivity reactions (e.g. angioedema, chest tightness, flushing).
Nervous system disorders: Headache, drowsiness, dizziness.
Psychiatric disorders: Insomnia, nervousness, sleep disorders or nightmares.
Skin and subcutaneous tissue disorders: Rash, urticaria, pruritus.
Monitoring Parameters
Monitor relief of symptoms.
Overdosage
Symptoms: Dizziness, drowsiness, fatigue and dry mouth. Management: Symptomatic and supportive treatment.
Drug Interactions
Increased plasma concentrations with erythromycin and ketoconazole. Reduced bioavailability and absorption with antacids containing Al and Mg.
Food Interaction
Decreased bioavailability with high-fat meals, fruit juice (e.g. apple, grapefruit, orange).
Lab Interference
May suppress the wheal and flare reactions to skin test antigens.
Action
Description: Fexofenadine is a non-sedating antihistamine and an active metabolite of terfenadine. It competes with histamine for H1-receptor on effector cells in the blood vessels, gastrointestinal tract and respiratory tract.
Onset: 2 hours.
Duration: 24 hours.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract. Bioavailability: Approx 33%; decreased with high-fat meals, fruit juice. Time to peak plasma concentration: Approx 2.6 hours (conventional tab); 2 hours (orally disintegrating tab); approx 1 hour (susp).
Distribution: Plasma protein binding: 60-70%, mainly to albumin and α1-acid glycoprotein.
Metabolism: Undergoes minimal metabolism in the liver (approx 5%) into methylester metabolite.
Excretion: Mainly via faeces (80%); urine (12%, as unchanged drug). Elimination half-life: 14.4 hours.
Chemical Structure

Chemical Structure Image
Fexofenadine

Source: National Center for Biotechnology Information. PubChem Database. Fexofenadine, CID=3348, https://pubchem.ncbi.nlm.nih.gov/compound/Fexofenadine (accessed on Jan. 20, 2020)

Storage
Store between 20-25°C.
MIMS Class
Antihistamines & Antiallergics
ATC Classification
R06AX26 - fexofenadine ; Belongs to the class of other antihistamines for systemic use.
References
Anon. Fexofenadine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/03/2022.

Buckingham R (ed). Fexofenadine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/02/2022.

Childrens Fexofenadine Hydrochloride Allergy Suspension (Taro Pharmaceuticals U.S.A., Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 10/02/2022.

Fexofenadine Cipla 120 mg Film-Coated Tablets (Cipla [EU] Limited). MHRA. https://products.mhra.gov.uk. Accessed 10/02/2022.

Fexofenadine HCL Tablet (Akron Pharma Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 10/02/2022.

Fexofenadine Hydrochloride 180 mg Film-Coated Tablets (Generics [UK] Limited t/a Mylan). MHRA. https://products.mhra.gov.uk. Accessed 10/02/2022.

Joint Formulary Committee. Fexofenadine Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/02/2022.

Pharmacy Retailing (NZ) Limited Trading as Healthcare Logistics. Telfast 6-11 Years 30 mg Film Coated Tablets; Telfast 60 mg Film Coated Tablets; Telfast 120 mg Film Coated Tablets; Telfast 180 mg Film Coated Tablets; Telfast Oral Liquid, 6 mg/mL Suspension data sheet 20 December 2021. Medsafe. http://www.medsafe.govt.nz. Accessed 10/02/2022.

Telfast 180 mg Tablets (DKSH Malaysia Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 10/02/2022.

Telfast 30 mg Film-Coated Tablets (Sanofi). MHRA. https://products.mhra.gov.uk. Accessed 10/02/2022.

Telfast 30 mg/5 mL Oral Suspension (DKSH Malaysia Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 10/02/2022.

Disclaimer: This information is independently developed by MIMS based on Fexofenadine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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