Flemex

Flemex

Manufacturer:

Medhaus

Distributor:

Medhaus
Full Prescribing Info
Contents
Dextromethorphan hydrobromide, guiafenesin.
Action
Pharmacologic Classification: Centrally acting Antitussive/Expectorant.
Pharmacology: Pharmacokinetics: Dextromethorphan Hydrobromide acts centrally to elevate the threshold for coughing. It has no analgesic or additive properties. The onset of antitussive action occurs in 15 to 30 minutes after administration and is of long duration.
Guiafenesin is well absorbed from gastrointestinal tract. It is metabolized and then excreted in the urine.
Indications/Uses
Flemex temporarily relieves cough due to minor throat and bronchial irritation as may occur with a cold and expectorant actions to help loosen phlegm and thin bronchial secretion to make cough more productive. It also helps relieve chest congestion.
Dosage/Direction for Use
<4yrs: do not use. 4-5yrs: 2.5-5mL every 4 hours. 6-11yrs: 5-10mL every 4 hours. Max 6 doses/day.
Overdosage
There have been reports of overdosage or accidental poisoning (usually in children) due to dextromethorphan, including rare fatalities. Naloxone may be effective in reversing toxicity.
Contraindications
Contraindicated in patients who are allergic (hypersensitive) to its active ingredients or other component of the product.
Severe and sometimes fatal reactions have been reported after use of dextromethorphan in patients receiving MAOI.
Special Precautions
Dextromethorphan preparation should not be given to patients at risk of developing respiratory failure. Caution is needed in patients with a history of asthma and it should not given during an acute attack. Care is also advisable in patients with bronchitis, emphysema, or in other conditions where chronic or persistent cough occurs.
Adverse Reactions
Gastrointestinal discomfort, nausea, and vomiting, and dizziness have occasionally been reported with guiafenesin and dextromethorphan, particularly in very large doses.
Abuse: Urinary calculi have been reported in patients consuming large quantities of over the counter preparations containing guiafenesin.
Drug Interactions
Dextromethorphan: Primarily metabolized by the cytochrome P450 isoenzyme CYP2D6; the possibility of interactions with inhibitors of this enzyme, including amiodarone, haloperidol, propafenone, quinidine, SSRIs, and thioridazine.
Storage
Store at temperatures not exceeding 30°C.
MIMS Class
Cough & Cold Preparations
ATC Classification
R05FA02 - opium derivatives and expectorants ; Belongs to the class of combinations of opium derivatives cough suppressants and expectorants. Used in the treatment of cough.
Presentation/Packing
Syr 60 mL.
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