PT Novell


Prosweal Healthcare
Concise Prescribing Info
Cryptococcosis including cryptococcal meningitis & infections of other sites (eg, pulmonary, cutaneous). Systemic candidiasis including candidemia, disseminated candidiasis & other forms of invasive candidal infections. Mucosal, genital candidiasis. Prevention of fungal infections in patients w/ malignancy predisposed to such infections as a result of cytotoxic chemotherapy or radiotherapy. Dermatomycosis & dermal candida infections. Deep endemic mycoses in immunocompetent patients, coccidioidomycosis, paracoccidioidomycosis, sporotrichosis & histoplasmosis.
Dosage/Direction for Use
Adult Cryptococcal meningitis & infections at other sites 400 mg on the 1st day followed by 200-400 mg once daily. At least 6-8 wk for cryptococcal meningitis. Prevention of relapse of cryptococcal meningitis in patient w/ AIDS, after receiving a full course of primary therapy Indefinitely at 200 mg daily. Candidemia, disseminated candidiasis & other invasive candidal infections 400 mg on the 1st day followed by 200 mg daily, may be increased to 400 mg daily. Oropharyngeal candidiasis 50-100 mg once daily for 7-14 days. If necessary, can be continued for longer periods in patient w/ severely compromised immune function. Atrophic oral candidiasis associated w/ dentures 50 mg once daily for 14 days w/ local antiseptic measures to the denture. Other candidal infections of mucosa except genital candidiasis (eg, esophagitis, non-invasive bronchopulmonary infections, candiduria, mucocutaneous candidiasis) 50-100 mg daily for 14-30 days. Prevention of relapse of oropharyngeal candidiasis in patient w/ AIDS, after receiving a full course of primary therapy 150 mg once wkly. Vag candidiasis & candida balanitis 150 mg as a single dose. Recurrent vag candidiasis 150 mg once mthly. Duration: 4-12 mth.  Prevention of candidiasis 50-400 mg once daily. Dermal infections including tinea pedis, corporis, cruris & candida 150 mg once wkly or 50 mg once daily. Duration: 2-4 wk but tinea pedis may require up to 6 wk. Tinea versicolor 300 mg once wkly for 2 wk; 3rd wkly dose of 300 mg may be needed, whereas, single dose of 300-400 mg may be sufficient. Alternate dosing: 50 mg once daily for 2-4 wk. Tinea unguium 150 mg once wkly. Deep endemic mycoses 200-400 mg daily for up to 2 yr. Duration: 11-24 mth w/ coccidioidomycosis, 2-7 mth w/ paracoccidioidomycosis, 1-16 mth w/ sporotrichosis & 3-17 mth w/ histoplasmosis. Childn Mucosal candidiasis 3 mg/kg daily. Loading dose: 6 mg/kg on the 1st day to achieve steady state levels more rapidly. Systemic candidiasis & cryptococcal infections 6-12 mg/kg daily. Suppression of relapse of cryptococcal meningitis in childn w/ AIDS 6 mg/kg once daily. Prevention of fungal infections in immunocompromised patient 3-12 mg/kg daily. Neonate <4 wk Same dosing w/ older childn in the 1st 2 wk every 72 hr. During wk 3-4, same dose should be given every 48 hr. Renal impairment Initially 50-400 mg loading dose.
Concomitant use w/ cisapride, terfenadine, astemizole, pimozide, quinidine, erythromycin.
Special Precautions
Liver & renal dysfunction. Hepatotoxicity. Discontinue if bullous lesions or erythema multiforme develops. Patients w/ potentially proarrhythmic conditions. Pregnancy & lactation.
Adverse Reactions
Headache; abdominal pain, diarrhea, nausea, vomiting; increased alanine, aspartate aminotransferase & alkaline phosphatase; rash.
Drug Interactions
Increased in plasma levels of cisapride & prolongation of QTc interval. Serious cardiac dysrhythmias secondary to prolongation of the QTc interval w/ terfenadine. May decrease clearance of astemizole. May inhibit pimozide & quinidine metabolism. Potential increase risk of cardiotoxicity & sudden heart death w/ erythromycin.
MIMS Class
ATC Classification
J02AC01 - fluconazole ; Belongs to the class of triazole and tetrazole derivatives. Used in the systemic treatment of mycotic infections.
Fluxar soln for infusion 2 mg/mL
100 mL x 1's
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