Vitamin B-complex, folic acid.
Each capsule contains: Thiamine mononitrate (Vit. B1) 200 mg, Pyridoxine HCl (Vit. B6) 50 mg, Cyanocobalamin (Vit. B12) 500 mcg, Folic acid 5 mg.
Folic acid, Thiamine (B1), Pyridoxine (B6) and Cyanocobalamin (B12) are members of the Vitamin B Group. All are essential co-factors for various metabolic processes including the synthesis of purine and pyrimidine nucleotides and hence in the synthesis of DNA. Thiamine is primarily involved in energy production in the body, especially in the brain. Vitamin B6 is particularly important in the formation of body proteins and structural compounds. Folic acid, also known as folate, is essential in cell division and DNA synthesis. Vitamin B12 is involved in many body processes and works very closely with folic acid. Folic acid and Vitamin B12 help cells to multiply and are important co-factors for the remethylation of homocysteine to methionine, hence in lowering plasma homocysteine levels. Vitamin B6 serves as co-factor in the conversion of homocysteine into cysteine and eventually into glutathione along the transulfuration pathway, thereby lowering plasma homocysteine levels.
For the treatment and prevention of folate, Vitamins B1, B6 and B12 deficiency states. For supplementation where Folate and Vitamin B12 are reduced due to intake of certain medications such as Fenofibrate, Metformin and Methotrexate. For lowering homocysteine levels to reduce risk of cardiovascular diseases, myocardial infarction, stroke, peripheral arterial vascular disease, and endothelial dysfunction, a common feature of type II diabetes. To regulate homocysteine levels in patients with chronic renal failure and to improve their response to recombinant human erythropoietin (rhEPO) therapy. Used as prophylactic where the vitamin requirements such as folic acid are increased, especially during pregnancy, and to prevent and reduce incidence of neural tube defects. Used in the treatment of megaloblastic anemias which may result from malabsorption syndromes such as sprue, idiopathic steatorrhea, celiac disease, intestinal reticulosis, regional jejunitis, jejunal diverticulosis, blind loop syndrome, and gastroenterostomy.
Take 1 capsule daily or as prescribed by the physician.
Caution is advised in patients who may have folate-dependent tumors.
It is generally well tolerated. Gastro-intestinal disturbances may occur. There are rare reports of hypersensitivity reactions to oral folic acid or Vitamin B12
Folic acid may be affected by a number of drugs and anticonvulsants, oral contraceptives, antituberculosis drugs, alcohol, and folic acid antagonists including aminopterin, methotrexate, pyrimethamine, trimethoprim, and sulfonamides which have been said to cause folic acid deficiency states.
Store at temperatures not exceeding 30°C, away from direct sunlight.
A11A - MULTIVITAMINS, COMBINATIONS ; Used as dietary supplements.