Treatment & prevention of folate deficiency state. Protection against neural tube defects in offspring of pregnant & women of childbearing potential. Treatment of folate-deficient megaloblastic anemia, chronic hemolytic states eg, thalassemia major or sickle-cell anemia.
Folate-deficient megaloblastic anemia 5 mg daily for 4 mth. Up to 15 mg daily may be necessary in malabsorption states. Chronic hemolytic states eg, thalassemia major or sickle-cell anemia 5 mg every 1-7 days. Women of childbearing potential at high risk of having pregnancy affected by neural tube defect4 or 5 mg daily starting before pregnancy & continued through the 1st trimester. Prophylaxis of folate deficiency in childn >12 yr undergoing dialysis 5-10 mg daily.