There are no data available from clinical trials on overdose with Forair, however data on overdose with both drugs are given as follows: The signs and symptoms of Salmeterol overdose are tremor, headache and tachycardia. The preferred antidotes are cardio selective beta-blocking agents, which should be used with caution in patients with a history of bronchospasm. If Forair therapy has to be withdrawn due to overdose of the beta agonist component of the drug, provision of appropriate replacement steroid therapy should be considered. Additionally, hypokalaemia can occur and potassium replacement should be considered.
Acute: Acute inhalation of Fluticasone propionate doses in excess of those recommended may lead to temporary suppression of adrenal function. This does not need emergency action as adrenal function is recovered in a few days, as verified by plasma cortical measurements.
Chronic overdose of inhaled Fluticasone propionate: Risk of adrenal suppression. Monitoring of adrenal reserve may be necessary. In cases of Fluticasone propionate overdose Forair therapy may still be continued at a suitable dosage for symptom control.