Alendronate Sodium: If taken at the same time it is likely that calcium supplements, antacids, and other oral medications will interfere with absorption of alendronate. Therefore, patients must wait at least one-half hour after taking ALENDRONATE SODIUM + CHOLECALCIFEROL (FOSAVANCE) before taking any other oral medication.
No other drug interactions of clinical significance are anticipated.
Concomitant use of HRT (estrogen ± progestin) and ALENDRONATE SODIUM (FOSAMAX) was assessed in two clinical studies of one or two years' duration in postmenopausal osteoporotic women. Combined use of ALENDRONATE SODIUM (FOSAMAX) and HRT resulted in greater increases in bone mass, together with greater decreases in bone turnover, than seen with either treatment alone. In these studies, the safety and tolerability profile of the combination was consistent with those of the individual treatments (see Clinical Studies, Concomitant use with estrogen/hormone replacement therapy under SIDE EFFECTS).
Specific interaction studies were not performed. ALENDRONATE SODIUM (FOSAMAX) was used in osteoporosis studies in men and postmenopausal women with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions.
Since NSAID use is associated with gastrointestinal irritation, caution should be used during concomitant use with alendronate.
Cholecalciferol: Olestra, mineral oils, orlistat, and bile acid sequestrants (e.g., cholestyramine, colestipol) may impair the absorption of vitamin D. Anticonvulsants, cimetidine, and thiazides may increase the catabolism of vitamin D.