Fusidic acid is a potent topical antibacterial agent. Betamethasone is an anti-inflammatory and antipruritic agent. Concentrations of 0.03-0.16 mcg/mL of fusidic acid inhibit nearly all strains of Staphylococcus aureus, including strains resistant to penicillin or to other antibiotics. Topically applied fusidic acid is also effective against Streptococci, Corynebacteria, Neisseria and certain Clostridia.
Pharmacokinetics: Betamethasone valerate is absorbed through the skin when applied topically. Fusidic acid penetrates normal or inflamed skin and achieves bactericidal concentrations down to the lower corium.