When steroids, particularly fluorinated steroids are applied for long periods of time (>4 weeks), atrophic striae is likely to occur.
Systemic absorption resulting in adrenal suppression may occur especially under occlusion with weekly doses of >30 g.
Prolonged use on flexures and intertriginous areas should be avoided.
Use in pregnancy: Topical administration of any corticosteroid to pregnant animals can cause abnormalities of foetal development. The relevance of this finding to human beings has not been established; however, topical steroids should not be used extensively over long periods.
Use in children: Babies and children up to 4 years should not be treated with dermal steroids for >3 weeks. In infants, the napkin may act as an occlusive dressing and increase absorption. Adrenal suppression is more likely to occur in infants and children.