Gastromec

Gastromec

domperidone

Manufacturer:

ACME

Distributor:

Unipharma

Marketer:

Euro Generics
Full Prescribing Info
Contents
Domperidone maleate.
Description
Each Film-Coated Tablet contains Domperidone (as maleate) 10 mg.
Domperidone is a dopamine receptor (D2) antagonist.
Domperidone is a selective peripheral dopamine antagonist at the D2 dopamine receptor in the Chemo-receptor Trigger Zone (CTZ) and stomach. Domperidone does not readily enter the central nervous system (the chemoreceptor trigger zone is considered to lie outside the blood brain barrier). Domperidone increases spontaneous gastric activity and antagonizes dopamine inhibition of gastric emptying. Domperidone has been shown to increase lower esophageal sphincter pressure and promotes esophageal and antral peristalsis and also increases pyloric dilatation. Domperidone increases the frequency, amplitude, duration of duodenal contraction and reduces the small bowel transit time. Domperidone has no acetylcholine like effect.
Indications/Uses
Domperidone is used as an antiemetic for the short-term treatment of nausea and vomiting of various aetiologies. It is also used for its prokinetic actions in dyspepsia and has been tried in diabetic gastroparesis.
Dosage/Direction for Use
Domperidone should be taken 15-30 minutes before a meal. The usual recommended oral dose is as follows: For Nausea and vomiting: Adult: 10-20 mg (1-2 tablet) every 6 hours.
Elderly: 10-20 mg (1-2 tablet) every 6 hours.
For symptomatic management of non-ulcer dyspepsia: 10 mg taken up to 4 times daily.
OR AS DIRECTED BY THE PHYSICIAN.
Overdosage
There are no reported cases of over dosage.
Contraindications
Domperidone is contraindicated to patients having known hypersensitivity to this drug and in case of neonates. Domperidone should not be used when gastrointestinal stimulation might be dangerous i.e. gastrointestinal hemorrhage, obstruction. perforation or immediately after surgery.
Special Precautions
Domperidone should be used with absolute caution in case of children because there may be an increased risk of extrapyramidal reactions in young children because of an incompletely developed blood brain barrier.
The safety of Domperidone has not been proven and it is, therefore, not recommended during pregnancy. Animal studies have not demonstrated teratogenic effect on the fetus. Domperidone may precipitate galactorrhea and improve postnatal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful. Domperidone is not recommended for chronic use or for the routine prophylaxis of postoperative nausea and vomiting.
Adverse Reactions
Extrapyramidal reactions are seen in 0.05% of patients in clinical studies. Domperidone may produce hyperprolactinemia (1.3%). This may result in galactorrhea, breast enlargement, soreness and reduced libido. Dry mouth (1.9%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itch (0.1%) may all follow treatment with Domperidone.
Drug Interactions
Domperidone may reduce the risk of hypoprolactinemic effect of bromocriptine. The action of Domperidone on GI function may be antagonized by antimuscarinics and opioid analgesics.
Caution For Usage
Foods, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription.
Storage
Store at temperatures not exceeding 30°C. Protect from light.
ATC Classification
A03FA03 - domperidone ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
Presentation/Packing
FC tab 10 mg x 100's.
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