Gel-Malicid

Gel-Malicid

aluminium hydroxide + magnesium hydroxide

Manufacturer:

Am-Europharma

Distributor:

EuroCare
Full Prescribing Info
Contents
Aluminum hydroxide, magnesium hydroxide.
Description
Each tablet contains: Aluminum Hydroxide 200 mg, Magnesium Hydroxide 100 mg.
Action
This product contains a combination of antacids, aluminum hydroxide and magnesium hydroxide, which effectively increase gastric pH by neutralizing the acid produced in the stomach.
Indications/Uses
For the symptomatic relief of hyperacidity associated with peptic ulcer, gastritis, esophagitis, and dyspepsia.
As adjunct to H2-blockers or proton pump inhibitors for the rapid relief of ulcer symptoms.
Dosage/Direction for Use
Recommended Adult Dose: 1 to 2 tablets one hour after each meal and at bedtime.
Or, as prescribed by a physician.
What to do if the patient misses a dose: If the patient misses a dose, just give the next dose and the subsequent doses at the recommended time or schedule.
Do not double the dose unless recommended by a doctor.
Overdosage
Signs and symptoms: Aluminum hydroxide may accumulate in bones, lungs and nerve tissues in patients with kidney failure. Large doses of chronic use of aluminum may also cause phosphorus depletion which is characterized by anorexia, malaise and muscle weakness. Prolonged use may cause kidney stones, osteomalacia (softening of bones) and osteoporosis.
Hypotension, nausea, vomiting, ECG change, respiratory and mental depression, and coma have also been reported with large dose of magnesium in patients with severe kidney disease.
What to do when the patient has taken more than the recommended dose: If the patient has taken more than the recommended dose, consult a doctor.
Contraindications
If patient is allergic to any ingredient in this product.
If patient has: Kidney disease; Intestinal obstruction; Appendicitis; Fecal impaction (solid, dry stool stuck in the rectum); Gastric outlet obstruction (narrowing of the opening from the stomach into the small intestine); Constipation; Phosphate depletion; Osteomalacia (softening of bones).
Special Precautions
Patients with advanced kidney disease are at risk of aluminum and magnesium accumulation and toxicity. Do not use this product in such patients.
Aluminum hydroxide maybe unsafe in patients with porphyria undergoing hemodialysis.
When to consult a doctor: Ask a doctor before use if the patient is: Pregnant or breastfeeding; taking other medicines; antacids may interact with certain medicines.
Stop use and ask a doctor if the patient needs to take this product for more than 14 days.
Use In Pregnancy & Lactation
Ask a doctor before use if the patient is: Pregnant or breastfeeding.
Adverse Reactions
The combination of aluminum hydroxide and magnesium hydroxide balances the side effects of diarrhea from magnesium hydroxide and constipation from aluminum hydroxide.
Excessive doses of aluminum hydroxide and magnesium hydroxide may result in high aluminum and magnesium levels in the blood in patients with kidney impairment.
Drug Interactions
Lowering the acidity of stomach contents decreases the absorption of iron, ketoconazole and tetracyclines. The absorption of tetracyclines is further reduced by its chelation with aluminum and magnesium ions. Tetracycline doses should be given 1 to 2 hours before or after doses of antacids.
Concurrent administration of antacids and orally-administered angiotensin-converting enzyme (ACE) inhibitors, digoxin, indomethacin, or iron salts may decrease the absorption of these drugs. Doses of these drugs should be spaced as far as possible from doses of antacids.
Antacid-induced increases in urine pH increase urinary excretion and decrease blood concentration of salicylates.
Antacid-induced increase in urinary pH may decrease excretion of weakly basic drugs and increase excretion of weakly acidic drugs.
Administration of a magnesium and aluminum hydroxide preparation with chlordiazepoxide decreases the rate of chlordiazepoxide absorption.
Antacids reduce the absorption of biphosphonates, (e.g. alendronate, etidronate, risedronate).
Interaction can be minimized by giving Aluminum hydroxide + Magnesium hydroxide and any other medication 2 to 3 hours apart.
Storage
Store at temperatures not exceeding 30°C. Protect from light.
ATC Classification
A02AD01 - ordinary salt combinations ; Belongs to the class of combinations and complexes of aluminium, calcium and magnesium-containing antacids.
Presentation/Packing
Tab (white, round, flat, beveled edge and plain on both sides) 100's.
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