Getzar Plus

Getzar Plus

losartan + hydrochlorothiazide

Manufacturer:

Hizon

Distributor:

Getz Pharma
Concise Prescribing Info
Contents
Per 50 mg/12.5 mg FC tab Losartan K 50 mg, hydrochlorothiazide 12.5 mg. Per 100 mg/25 mg FC tab Losartan K 100 mg, hydrochlorothiazide 25 mg
Indications/Uses
HTN including patients w/ left ventricular hypertrophy; diabetic nephropathy in type 2 DM.
Dosage/Direction for Use
Usual dose: 50 mg/12.5 mg once daily, may be increased to 100 mg/25 mg daily as a single dose or in 2 divided doses. Elderly >75 yr, patient w/ moderate to severe renal impairment (CrCl <20 mL/min) or intravascular fluid depletion Initially 25 mg once daily.
Administration
May be taken with or without food.
Contraindications
Severe renal impairment (CrCl <30 mL/min) or anuria, Addison's disease, preexisting hypercalcemia. Pregnancy.
Special Precautions
Renal artery stenosis/impairment. Monitor fluid & electrolyte imbalance especially in the presence of vomiting or during parenteral fluid therapy.
Adverse Reactions
Losartan K: Dizziness & dose-related orthostatic hypotension; hyperkalemia. Hydrochlorothiazide: Metabolic disturbances at high dose; hyperglycemia & glycosuria; hyperuricemia & gout-precipitated attacks; electrolyte imbalances including hypochloremic alkalosis, hyponatremia & hypokalemia.
Drug Interactions
Losartan K: Rifampicin & fluconazole; K-sparing diuretics, K supplements or K-containing salt substitutes. Hydrochlorothiazide: Alcohol, barbiturates or narcotics; antidiabetic drugs (oral agents & insulin); other antihypertensive drugs; cholestyramine & colestipol resins; corticosteroids, ACTH; pressor amines (eg, adrenaline).
ATC Classification
C09DA01 - losartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Getzar Plus 100 mg/25 mg FC tab
Packing/Price
100's (P2,500/box)
Form
Getzar Plus 50 mg/12.5 mg FC tab
Packing/Price
50's (P937.5/box)
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