Pharmacology: Gliclazide is a sulfonylurea antidiabetic.
Pharmacokinetics: Gliclazide is readily absorbed from the gastrointestinal tract. It is extensively bound to plasma proteins. The half-life (t½) is about 10-12 hrs. Gliclazide is extensively metabolized in the liver to metabolites that have no significant hypoglycemic activity. Metabolites and a small amount of unchanged drug are excreted in the urine.
Special Populations: Elderly: Because its effects are less prolonged than those of chlorpropamide or glibenclamide, gliclazide may be more suitable for elderly patients who are prone to hypoglycemia with longer-acting sulfonylureas.