Taiwan Biotech


New Smart Formulae
Concise Prescribing Info
Dosage/Direction for Use
Initially 1 mg once daily, increase gradually at intervals of 1-2 wk according to the following dose steps: 1 mg, 2 mg, 3 mg, 4 mg, 6 mg. Max: 8 mg/day. Patient w/ well-controlled diabetes 1-4 mg daily.
Should be taken with food: Take immediately before the 1st main meal of the day. Do not skip meals.
Hypersensitivity to glimepiride, other sulphonylureas or sulfonamides. Impaired liver & moderate to more severe renal function. Pregnancy & lactation. Childn.
Special Precautions
Increased risk of CV mortality. Monitor blood glucose level regularly. Careful monitoring for increased risk of hypoglycemia.
Adverse Reactions
Headache, ravenous hunger, nausea, vomiting, lassitude, sleepiness, sleep disorders, restlessness, aggressiveness, impaired concentration, impaired alertness & reactions, depression, confusion, speech disorders, aphasia, visual disorders, tremor, paresis, sensory disturbances, dizziness, helplessness, loss of control, delirium, cerebral convulsions, somnolence & loss of consciousness up to & including coma, shallow resp, bradycardia. Signs of adrenergic counter-regulation eg, sweating, clammy skin, anxiety, tachycardia, HTN, palpitations, angina pectoris & cardiac arrhythmias. Temporary visual impairment; sensations of pressure or fullness in the epigastrium, abdominal pain & diarrhea, liver enzyme elevation, liver function impairment, hepatitis. Thrombocytopenia, leucopenia; haemolytic anemia or erythrocytopenia, granulocytopenia, agranulocytosis & pancytopenia; itching, urticaria or rashes; dyspnoea; decreased serum Na conc, allergic vasculitis.
Drug Interactions
Potentiation of blood glucose-lowering effect w/ insulin & other oral antidiabetics, MAOIs, ACE inhibitors, miconazole, anabolic steroids & male sex hormones, para-aminosalicylic acid, chloramphenicol, pentoxifyline (high dose parenteral), coumarin derivatives, phenylbutazone, azapropazone, oxyphenbutazone, cyclophospamide, probenecid, disopyramide, quinolones, fenfluramine, salicylates, fenyramidol, sulphinpyrazone, fibrates, sulfonamides, fluoxetine, tetracyclines, guanethidine, tritoqualine, trofosfamide. Weakening of blood-glucose-lowering effect w/ acetazolamide, laxatives (after protracted use), barbiturates & nicotinic acid.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
Glimarex tab 2 mg
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