Pregnancy: Recent information suggested that abnormal blood glucose levels during pregnancy are associated with higher incidence of congenital abnormalities. Most experts suggest insulin be used to maintain the blood glucose levels as close to normal as possible. The use of Gliclazide and Metformin combination is not recommended for use in pregnancy.
Lactation: Studies in lactating rats show that Metformin is excreted in to milk and reaches levels comparable to those in plasma. Similar studies have not been conducted on nursing mothers. It is not known whether Gliclazide or its metabolites are excreted in breast milk. Hence, the use of Gliclazide and Metformin combination is not recommended for use in lactating mothers, and if the diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.