Endure Medical
Concise Prescribing Info
Cefoxitin Na
Infections due to sensitive gm +ve & gm -ve bacteria; surgical prophylaxis.
Dosage/Direction for Use
IM/IV Adult 1-2 g 8 hrly or 4-6 hrly. Severe infections Up to 12 g daily. Childn & neonate ≤1 wk 20-40 mg/kg 12 hrly. 1-4 wk 8 hrly. Older infant & childn 6-8 hrly. Severe infections Up to 200 mg/kg daily. Max: 12 g daily. Uncomplicated UTI 1 g bid. Renal impairment Initial loading dose: 1-2 g. Maintenance doses: CrCl 30-50 mL/min 1-2 g 8-12 hrly; 10-29 mL/min 1-2 g 12-24 hrly; 5-9 mL/min 0.5-1 g 12-24 hrly; <5 mL/min 0.5-1 g 24-48 hrly. Uncomplicated gonorrhea 2 g as single dose IM w/ 1 g probenecid orally. Prophylaxis for surgical infection 2 g IM or IV 30-60 min pre-op then 6 hrly for not >24 hr. Infant & childn 30-40 mg/kg same time intervals as adult. Neonate 30-40 mg/kg 8-12 hrly. Caesarean section 2 g IV as soon as umbilical cord is clamped. If necessary, 3 dose regimen w/ 2 g dose 4-8 hrly after the initial dose.
Patients w/ porphyria. Hypersensitivity to cephalosporins.
Special Precautions
Renal impairment. Monitor renal & hematological status. +ve Coombs' test.
Adverse Reactions
Skin rashes, urticaria, eosinophilia, fever, reactions resembling serum sickness & anaphylaxis; +ve Coombs' test; neutropenia & thrombocytopenia; bleeding complications, nephrotoxicity, acute renal tubular necrosis, acute interstitial nephritis. CNS toxicity, convulsions; pseudomembranous colitis. Pain at inj site & thrombophlebitis.
Drug Interactions
MIMS Class
ATC Classification
J01DC01 - cefoxitin ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Haxotin powd for inj 1 g
(vial) 10 × 1's
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