Hemadone

Hemadone

Manufacturer:

Oboi

Distributor:

Phil Pharmawealth
Full Prescribing Info
Contents
Menadione sodium bisulfite.
Description
Each mL contains: Menadione sodium bisulfite BP 10 mg.
Action
Menadione Sodium Bisulfite is necessary for the formation of prothrombinogen and other blood clotting factors in the liver.
During clotting, circulating prothrombin is required for the production of thrombin; in turn the thrombin converts fibrinogen to fibrin, the network of which constitutes the clot. It is obvious from this description that interference with formation of prothrombin will reduce the clotting tendency of the blood. In a deficiency of the vitamin, a condition of hypoprothrombinemia occurs, and blood clotting time may be greatly or even indefinite prolonged. Internal or external hemorrhages may ensure either spontaneously or following injury or surgery.
Menadione Sodium Bisulfite is a dietary principle necessary for the normal biosynthesis of the blood clotting factors: II (Prothrombin), VII (Procovertin), IX (Plasma Thromboplastin Component) and X (Stuart Factor) in the liver. Menadione in the Sodium Bisulfite salt form is water-soluble but is at least as active as the natural vitamin K. Being water-soluble, menadione sodium bisulfite is absorbable in the gastrointestinal tract even in the absence of bile salts. It is also readily absorbed when administered by intramuscular injection. It is concentrated in the liver. Metabolites of the vitamin are excreted via the bile and urine.
Indications/Uses
Menadione or its sodium bisulfite derivatives and other vitamin K preparations are used in the treatment of the hemorrhagic diathesis of obstructive jaundice, the hemorrhagic states associated with primary hepatic disease, the hemorrhagic states which accompany certain intestinal disease such as ulcerative colitis, sprue and celiac disease, the physiologic hypoprothrombinemia of the new born, the rare cases of dietary deficiency of vitamin K, to counteract the effect of bishydoxycoumarin (DICUMAROL) overdosage and blood coagulation disorders due to deficiency of blood clotting factor II, factor VII, factor IX and/or factor X. The hemorrhagic state associated with primary hepatic disease is poorly controlled by Menadione or other vitamin K analogues. It is also indicated to increase the formation of prothrombin and to reduce the clotting time blood.
Dosage/Direction for Use
10 mg/day (adult and pediatric age) by intramuscular injection.
Contraindications
Hypersensitivity to menadione sodium bisulfite. Not to be administered to mothers during the last weeks of pregnancy.
Warnings
This product contains Sodium Metabisulfite that may cause allergic type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible persons.
May result in the production of hemolytic anemia, hyperbilirubinemia and kernicterus in the newborn, particularly in premature babies. Will not counteract the anticoagulant action of heparin.
Special Precautions
Use with caution in patients with liver deficiency. Repeated determinations of prothrombin time should be done to help determine the dose and duration of treatment.
Storage
Store at temperature not exceeding 30°C.
MIMS Class
ATC Classification
B02BA02 - menadione ; Belongs to the class of vitamin K. Used in the treatment of hemorrhage.
Presentation/Packing
Soln for inj (amp) 10 mg/mL x 1 mL x 100's.
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