Heme-Up FA

Heme-Up FA




BSV Bioscience Phils


Full Prescribing Info
Carbonyl iron, zinc sulfate, folic acid.
Each capsule contains Elemental Iron 50 mg (in the form of Carbonyl Iron), Zinc Sulfate Monohydrate 61.8 mg (Equivalent to 22.5 mg Elemental Zinc), Folic Acid 500 mcg.
Pharmacology: Pharmacodynamics: Mechanism of Action: Carbonyl Iron is a form of the mineral iron. Iron is important for many functions in the body, especially for the transport of oxygen in the blood. Carbonyl Iron is used as a dietary supplement, and to prevent and to treat iron deficiencies and iron deficiency anemia.
Zinc is essential to numerous physiological processes, including the function of many enzymes in the body. Deficiency may lead to poor night vision, slow healing of wounds, poor sexual development and function in males, poor appetite (perhaps owing to a decrease in the sense of taste and smell), a reduced ability to ward off infections, diarrhea, dermatitis, and, in children, retarded growth.
Folic acid enhances chemical reactions that contribute to the production of red blood cells, the manufacture of DNA needed for cell replication, and the metabolism of amino acids (compounds necessary for the manufacture of proteins).
Pharmacokinetics: Carbonyl Iron requires stomach acid for its absorption. Iron in excess of need is stored principally as ferritin in the reticuloendothelial system of liver, spleen, bone marrow and other organs. Iron is released from ferritin in the form of ferrous (Fe II) iron and enters the plasma where it is oxidized by ceruplasmin to ferric (Fe III) iron and taken up and transported in the plasma by transferrin. The body has a limited capacity to excrete iron. Very little iron is excreted by the kidneys or via the biliary route. Some iron losses occur through sloughing of skin and mucosal cells. 20% to 30% of dietary Zinc is absorbed from the GI tract. The main excretion route is through the intestine. Only minor amounts are lost in urine (-2%).
Folic acid is rapidly absorbed from the gastrointestinal tract, mainly from the duodenum and jejunum. Dietary folates are stated to be less well absorbed than crystalline folic acid. The naturally occurring folate polyglutamates are largely deconjugated and reduced by dihydrofolate reductase in the intestine to form 5-methyltetrahydrofolate, which appears in the portal circulation, where it is extensively bound to plasma proteins. Folic acid administered therapeutically enters the portal circulation largely unchanged. Since it is a poor substrate for reduction by dihydrofolate reductase, it is converted to the metabolically active form 5-methyltetrahydrofolate in the plasma and liver.
The principal storage site of folate is the liver, it is also actively concentrated in the CSF, Folate undergoes enterohepatic circulation. Folate metabolites are eliminated in the urine and folate in excess of body requirements is excreted unchanged in the urine. Folate is distributed into breast milk, Folic acid is removed by haemodialysis.
Used in the treatment of Iron deficiency anemia and other anemias like megaloblastic anemia (due to folic acid deficiency), treatment of Zinc deficiency, which may occur specially during pregnancy.
Folic acid is also used to prevent Neural Tube Birth Defect
Dosage/Direction for Use
Route of Administration: Oral Route.
Dosage: 1 Capsule a day, or as directed by the physician.
Symptoms of a Carbonyl Iron overdose include decreased energy, nausea, vomiting, abdominal pain, tarry stools, a weak, rapid pulse, fever, coma, seizures, and death.
Symptoms of a Zinc Sulfate overdose include nausea, severe vomiting, dehydration, and restlessness.
Iron supplements are contraindicated in those with hemachromatosis and hemosiderosis.
Contraindicated in those who are hypersensitive to any components.
Special Precautions
Folic acid in doses above 0.1 mg daily may obscure pernicious anemia in that, hematologic remission can occur while neurological manifestations remain progressive.
Those with elevated serum ferritin levels should be extremely cautious in the use of iron supplements. Iron supplements can be highly toxic or lethal to small children.
Iron supplements should be used with extreme caution in those with chronic liver failure, alcoholic cirrhosis, chronic alcoholism and pancreatic insufficiency.
Carbonyl iron requires adequate stomach acid for absorption. Therefore, carbonyl iron should be taken with food and should not be used with antacids.
Iron should be used with caution in those with a history of gastritis, peptic ulcer disease or gastrointestinal bleeding.
Side Effects
Side effects occur rarely, the side effects which to a lesser extent are Allergic sensitization.
Allergic reaction (difficulty of breathing; closing of the throat; swelling of the lips, tongue, or face, or hives).
Nausea, epigastric distress, diarrhoea, constipation and black stools.
Drug Interactions
Drugs which may cause folate deficiency include phenytoin, isoniazid, primidone, barbiturates, oral contraceptives, ethanol, sulfasalazine, cycloserine, glutethamide, methotrexate, pyrimethamine, trimethoprim and triamterene.
Zinc interferes with captopril, absorption of Tetracycline antibiotics, Thiazide & Potassium-sparing diuretics. It decreases the absorption and effectiveness of Fluoroquinolones antibiotics (Cipro, Levaquin), Iron supplement.
Acid Pump Inhibitors: (Lansoprazole, omeprazole, pantoprazole, rabeprazole).
Antacids: Aluminum-or-magnesium-containing antacids.
Bisphosphonates (alendronate, etidronate, risedronate).
H2 Blockers (cimetidine, famotidine, nizatidine, ranitidine).
Quinolones (ciprofloxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, sparfloxacin, trovafloxacin).
Store at temperatures not exceeding 30°C.
ATC Classification
B03AD - Iron in combination with folic acid ; Used in the treatment of anemia
Cap 30's.
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