Himox

Himox

amoxicillin

Manufacturer:

Asian Antibiotics

Distributor:

UNILAB, Inc
Concise Prescribing Info
Contents
Amoxicillin trihydrate
Indications/Uses
Infections caused by susceptible organisms including upper & lower resp tract, GIT, GUT, skin & skin structure, bone (eg, osteomyelitis), gall bladder/biliary tract, H. pylori infections. Lyme disease; dental abscess. Prophylaxis for endocarditis;prevention of bacteremia, associated w/ procedures eg, dental extraction in patients at risk of developing bacterial endocarditis.
Dosage/Direction for Use
Adult 250-500 mg every 8 hr or 500 mg every 12 hr depending on the type & severity of infection. Max: 6 g/day in divided doses. Ear, nose, throat, GUT, skin & skin structure infections Mild to moderate: 250 mg every 8 hr or 500 mg every 12 hr. Severe: 500 mg every 8 hr. Mild to moderate lower resp tract infections 500 mg every 8 hr. H. pylori infection to reduce the risk of recurrent duodenal ulcer Triple therapy regimen: Amoxicillin 1 g + clarithromycin 500 mg + omeprazole 20 mg each given every 12 hr for 10 days. Dual therapy regimen: Amoxicillin 1 g + lansoprazole 30 mg each given every 8 hr for 14 days. Lyme disease For isolated erythema chronicum migrans: 4 g/day. For generalized manifestations: 6 g/day. Endocarditis prophylaxis for dental procedures 2 g as single dose 30-60 min before procedure. Infant >3 mth & childn <40 kg Usual dose: 25-50 mg/kg/day in divided doses every 8 or 12 hr. Ear, nose, throat, genitourinary tract, skin and skin structure infections Mild to moderate: 25 mg/kg/day every 12 hr or 20 mg/kg/day every 8 hr. Severe: 45 mg/kg/day every 12 hr or 40 mg/kg/day every 8 hr. Acute otitis media 80-90 mg/kg/day every 12 hr. LRTI 45 mg/kg/day every 12 hr. Endocarditis prophylaxis for dental procedures Childn 50 mg/kg as single dose given 30-60 min before procedure. Neonates and infant ≤3 mth Usual dose: 20-30 mg/kg/day in divided doses every 12 hr. Renal impairment CrCl 10-30 mL/min 250 or 500 mg every 12 hr in adult & childn ≥40 kg OR 15 mg/kg/day every 12 hr in childn <40 kg. CrCl <10 mL/min 250 or 500 mg every 24 hr in adult & childn ≥40 kg OR 15 mg/kg as single daily dose in childn <40 kg.
Administration
May be taken with or without food: May be taken w/ meals for better absorption & to reduce GI discomfort.
Special Precautions
Hypersensitivity to amoxicillin, penicillins, cephalosporins & multiple allergens. Discontinue if allergic reaction occurs. C. difficile-associated diarrhea & colitis have been reported. Maintain adequate fluid intake & urinary output to reduce the possibility of crystalluria in high doses. Long term or repeated use. Hepatic & renal impairment. Lactation. Childn ≤3 mth.
Adverse Reactions
Anaphylaxis, serum sickness-like reactions, severe allergic reactions including angioedema, exanthema, acute & generalized exanthematous pustulosis, bullous & exfoliative dermatitis, erythematous maculopapular rashes, erythema multiforme, hypersensitivity vasculitis, mucocutaneous/oral & vag candidiasis, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis; nausea, vomiting, diarrhea, black "hairy" tongue, C. difficile-associated diarrhea & colitis, hemorrhagic colitis, acute, transient enterocolitis w/ severe abdominal pain & bloody diarrhea; glossitis, stomatitis, epigastric distress, gastritis, flatulence, soft stools, loss of appetite/anorexia, enanthemas/sore mouth or tongue, dry mouth, taste disturbances; agitation, anxiety, behavioral changes, confusion, convulsions (at extremely high doses), dizziness, reversible hyperactivity, hyperkinesia, insomnia; anemia including hemolytic anemia, agranulocytosis, abnormal platelet aggregation, eosinophilia, leukopenia, neutropenia, prolongation of bleeding time, prothrombin time & activated partial thromboplastin time, thrombocytopenia, thrombocytopenic purpura; moderate rise in AST &/or ALT, transient increases in serum alkaline phosphatase and lactate dehydrogenase levels; hepatic dysfunction including cholestatic jaundice, hepatic cholestasis & acute cytolytic hepatitis; acute interstitial nephritis, crystalluria.
Drug Interactions
Increased incidence of skin rashes w/ allopurinol. Prolongation of prothrombin time w/ anticoagulants. May interfere w/ the bactericidal effects w/ bacteriostatic agents eg, chloramphenicol, macrolides, sulfonamides & tetracyclines). Synergistic bactericidal effect w/ β-lactamase inhibitors. May increase absorption of digoxin. May decrease renal clearance of methotrexate. May reduce estrogen reabsorption & efficacy of OCs. Increased & prolonged blood levels w/ probenecid. False +ve reaction in Clinitest, Benedict's soln. May interfere w/ protein testing when colorimetric methods are used.
MIMS Class
ATC Classification
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Presentation/Packing
Form
Himox oral susp 250 mg/5 mL
Packing/Price
105 mL x 1's;60 mL x 1's
Form
Himox cap 500 mg
Packing/Price
100's
Form
Himox oral susp 125 mg/5 mL
Packing/Price
105 mL x 1's;60 mL x 1's
Form
Himox oral drops 100 mg/mL
Packing/Price
10 mL x 1's
Form
Himox cap 250 mg
Packing/Price
100's
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