Histacort

Histacort

Manufacturer:

Asian Antibiotics

Distributor:

UNILAB, Inc
Concise Prescribing Info
Contents
Chlorpheniramine maleate 2 mg, prednisolone 2 mg
Indications/Uses
Symptomatic relief of allergy eg, hay fever, urticaria, emergency treatment of anaphylactic reactions & other allergic & inflammatory conditions.
Dosage/Direction for Use
Administration
Should be taken with food: Take after meals & at bedtime.
Contraindications
Hypersensitivity. Systemic fungal infections. Patients receiving MAOIs. Newborn & premature infants.
Special Precautions
Prednisolone: May produce reversible hypothalamic-pituitary adrenal suppression after w/drawal of treatment. Dose adjustment is necessary in hypothyroid & hyperthyroid patients. May decrease resistance & inability to localize infection when corticosteroids are used. Restrict use in active TB to cases of fulminating or disseminated TB. Latent TB or tuberculin reactivity. Persons who are on drugs which suppress the immune system. Do not undertake other immunization procedures while on treatment, especially on high dose, because of possible hazards of neurological complications & a lack of Ab response. Latent or active amoebiasis should be ruled out before initiating corticosteroid therapy in any patient who has spent time in the tropics or in any patient w/ unexplained diarrhea. Cerebral malaria. Dietary salt restriction & K supplementation may be necessary. Prolonged use may produce posterior subcapsular cataracts, glaucoma w/ possible damage to optical nerves. Gradual reduction. Patients w/ cirrhosis; ocular herpes simplex; nonspecific ulcerative colitis. Existing emotional instability or psychotic tendencies may be aggravated. Hypothrombinemia. May increase or decrease motility & number of spermatozoa in some patients. Chlorphenamine maleate: Patients w/ narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, prostatic hypertrophy or bladder neck obstruction, CV disease, HTN, increased IOP or hyperthyroidism; epilepsy. May affect ability to drive & use machines. Renal impairment. Pregnancy & lactation. Elderly. Neonates & childn <1 yr.
Adverse Reactions
Prednisolone: Na & fluid retention, CHF, K loss, hypokalemic alkalosis, HTN; muscle weakness, steroid myopathy, muscle mass loss, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral & humeral heads, pathologic fracture of long bones; peptic ulcer w/ possible perforation & hemorrhage, pancreatitis, abdominal distention, elevation in serum liver enzyme levels which are usual reversible upon discontinuation of treatment, ulcerative esophagitis; impaired wound healing, thin fragile skin, petechiae & ecchymoses, facial erythema, increased sweating; suppress reactions to skin tests, urticaria, edema; convulsions, increased intracranial pressure w/ papilledema or pseudo-tumor cerebri usually after treatment, psychiatric disorders, vertigo, headache; menstrual irregularities, development of Cushingoid state, suppression of growth in childn, hirsutism, secondary adrenocortical & pituitary unresponsiveness, decreased carbohydrate tolerance, manifestations of latent DM, increased requirements for insulin or oral hypoglycemic agents in diabetes; posterior subcapsular cataracts, increased IOP, glaucoma, exophthalmos; negative nitrogen balance; increased susceptibility to infections, appetite, malaise, nausea, wt gain. Chlorphenamine maleate: Slight to moderate drowsiness, dry mouth, blurred vision.; allergic sensitization; bone marrow depression, exfoliative dermatitis; facial dyskinesias; affect the senses of smell & taste.
Drug Interactions
Prednisolone: Lessened effect w/ anticonvulsants, rifampicin & other drugs that stimulate hepatic metabolism. Decreased metabolism w/ cyclosporin. Reduced plasma t½ w/ corticosteroids. Altered plasma protein binding & metabolism w/ OCs. May lower plasma salicylate levels of aspirin & NSAIDs. Impaired absorption w/ antacids. May increase blood glucose conc w/ insulin & other antidiabetic agents. Increased clearance & decreased plasma t½ w/ carbimazole or methimazole. Diminished response to toxoids & live inactivated vaccines. Enhanced K-wasting effect w/ K-depleting drugs. Chlorphenamine maleate: May enhance sedative effects of CNS depressants. Additive antimuscarinic action w/ other antimuscarinic drugs.
ATC Classification
R06AB54 - chlorphenamine, combinations ; Belongs to the class of substituted alkylamines used as systemic antihistamines.
Presentation/Packing
Form
Histacort tab
Packing/Price
100's
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