Dosage: Adult Dosage: Premedication: 50 to 100 micrograms (1 to 2 mL) fentanyl administered intramuscularly 30 to 60 minutes prior to surgery (modified for high risk patients).
Adjunct to general anesthesia induction: 50 to 100 micrograms (1 to 2 mL) administered intravenously and repeated at 2 to 3 minute intervals, until the desired effect is achieved (25 to 50 micrograms is recommended for high-risk patients). 25 to 50 micrograms (0.5 to 1 mL) should be administered intravenously or intramuscularly when movement and/or changes in vital signs indicate surgical stress or lightening of analgesia.
Adjunct to regional anesthesia: 50 to 100 micrograms administered intramuscularly or by slow intravenous injection.
Postoperatively: 50 to 100 micrograms administered intramuscularly repeated in 1 to 2 hours as needed.
Children's dosage: Do not use Fentanyl Citrate in children less than 2 years of age. For children aged between 2 to 12 years, fentanyl may be used for induction and maintenance at a reduced level as low as 20 to 30 micrograms per 10 kg bodyweight.
Use in elderly patients: Elderly patients may require lower doses of fentanyl and a varied dosage regimen as they may be more susceptible to adverse effects, such as respiratory depression and cardiovascular effects.
Method of Administration: Fentanyl citrate is administered by intramuscular or intravenous injection only.
The dosage of fentanyl should be given in the smallest effective dose and as infrequently as possible to minimize the development of tolerance and physical dependence. Dosage should be individualized to take into account physical condition and reactions with other drugs.
Reduced dosage is generally indicated for high-risk patients, including geriatric or debilitated patients, or those who have received other CNS depressant drugs. When used in conjunction with other CNS depressants as low as 25 to 33% of the usual dose is recommended.
Contains no antimicrobial agent. Product is for single use in one patient only. Discard any residue.
Dosage Adjustments: Renal impairment: Fentanyl should be used with caution in patients with impaired renal function.
Hepatic impairment: Fentanyl should be used with caution in patients with impaired hepatic function.