Immunoglobulins may interfere with the ability of live vaccines to induce an immune response and a suitable interval should be considered during co-administration. The ability of vaccines to induce an immune response can be influenced by the recent use of other vaccines or immunoglobulins. Live vaccines should either be given simultaneously (but at different sites) or an interval of at least 3 weeks allowed between administration. Live vaccines should normally he given at least 3 weeks before or at least 3 months after the use of immunoglobulin.
However, travelers should receive appropriate vaccines regardless of these limitations if time is short. Intravenous immunoglobulin preparations should be used with caution in patients with renal impairment. Immunoglobulin products containing sucrose may be associated with an increased risk of inducing acute renal failure. The incidence of renal failure appears to be greatest with immunoglobulin products containing sucrose.