Transferring to another type or brand, change in strength, species, &/or method of manufacture of insulin, uncorrected hypoglycemic or hyperglycemic reactions, use of inadequate dosages or discontinuation of treatment, diseases of the adrenal, pituitary, or thyroid gland, renal or hepatic impairment. May increase insulin requirements during illness or emotional disturbances. Change in physical activity or usual diet, combination of thiazolidinediones & insulin in patients w/ underlying cardiac disease. Pregnancy.