Salbutamol + Ipratropium bromide (i-BREATH PLUS) Metered Dose Inhaler has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines and steroids, commonly used in the treatment of COPD. No formal drug interaction studies have been performed with Salbutamol + Ipratropium bromide (i-BREATH PLUS) Metered Dose Inhaler and these or other medications commonly used in the treatment of COPD. Ipratropium Bromide should be co-administered cautiously with other anticholinergic agents and sympathomimetic agents, which may increase risk of adverse cardiovascular effects. Beta2-agonist containing drugs, like Salbutamol + Ipratropium bromide (i-BREATH PLUS) should be administered with extreme caution to patients with non-potassium sparing diuretics, monoamine oxidase inhibitors or tricyclic antidepressants.
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