Combination therapy for the treatment of colorectal cancer
Irinotecan 125 mg/m2
as IV 90 min on days 1, 8, 15 & 22 followed by leucovorin 20 mg/m2
as IV bolus on same days. 5-FU 500 mg immediately administer after administration of leucovorin, thereafter, additional courses are repeated after every 6 wk (4 wk on therapy, 2 wk off therapy).