Icox

Icox

celecoxib

Manufacturer:

Medico Remedies

Distributor:

Bell-Kenz Pharma
Concise Prescribing Info
Contents
Celecoxib
Indications/Uses
RA including juvenile idiopathic arthritis, OA & ankylosing spondylitis. Adjunctive treatment of adenomatous colorectal polyps. Management of acute pain & dysmenorrhea.
Dosage/Direction for Use
Adult OA 200 mg daily as a single dose or in 2 divided doses. May be increased up to 200 mg bid if necessary. RA 100-200 mg bid. Ankylosing spondylitis Initially 200 mg daily as single dose or in 2 divided doses. Pain & dysmenorrhea Initially 400 mg followed by an additional 200 mg on the 1st day, then 200 mg bid thereafter. Adenomatous colorectal polyps in patient w/ familial adenomatous polyposis 400 mg bid. Juvenile idiopathic arthritis Childn ≥2 yr weighing >25 kg 100 mg bid, 10-25 kg 50 mg bid.
Administration
May be taken with or without food: Dose for adenomatous colorectal polyps must be given w/ meals.
Contraindications
Hypersensitivity to sulfonamides. History of stroke (CVA), heart attack (MI, CABG), uncontrolled HTN & CHF NYHA II-IV. Inflammatory bowel disease & renal impairment (CrCl <30 mL/min).
Special Precautions
History of ischaemic heart disease, peripheral arterial or cerebrovascular disease; significant risk factors for CV disease eg, HTN, hyperlipidaemia & DM. Discontinue use if signs or symptoms of organ toxicity develop; if skin rash & signs of hypersensitivity appear. Potential GI (gastric & liver) & renal toxicities. Allergy to NSAIDs & asthma. Avoid smoking. Dehydrated patients. Not to be used w/ severe hepatic impairment (Child-Pugh C).
Adverse Reactions
Serious skin reactions eg, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis; hypersensitivity reactions including anaphylaxis & angioedema.
Drug Interactions
May result in changes in plasma conc w/ drugs that inhibit or induce or are metabolized by CYP450 isoenzyme CYP2C9. Increased plasma conc w/ fluconazole. Potential effect on drugs metabolized by isoenzyme CYP2D6.
ATC Classification
M01AH01 - celecoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.
Presentation/Packing
Form
Icox cap 200 mg
Packing/Price
100's (P26.25/cap, P2,625/box)
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