Usual Dose: 250 mg every 6 hrs. This may be increased up to ≥4 g daily according to the severity of the infection.
Age, weight and severity of the infection are important factors in determining the proper dosage. The usual regimen is 30-50 mg/kg/day in divided doses. For more severe infections, this dosage may be doubled.
If administration is desired on a twice-a-day schedule in either adults or children, ½ of the total daily dose may be given every 12 hrs. Twice-a-day dosing is not recommended with doses >1 g daily are administered.
For the treatment of streptococcal pharyngitis and tonsillitis, the usual dosage range is 20-50 mg/kg/day in divided doses (see table).
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In the treatment of group A β-hemolytic streptococcal infections, a therapeutic dosage of erythromycin should be administered for at least 10 days.
In continuous prophylaxis of streptococcal infections in persons with a history of rheumatic heart disease, the dosage is 250 mg twice a day.
For prophylaxis against bacterial endocarditis in penicillin allergic patients with congenital heart disease, rheumatic or other acquired valvular heart disease when undergoing dental procedures or surgical procedures of the upper respiratory tract. The dosage schedule for adults is 1 g (20 mg/kg for children) orally 1 hr before the procedure and then 500 mg (10 mg/kg for children) orally 6 hrs later.
A regimen of erythromycin estolate 20 g in divided doses over a period of 10 days has been shown to be effective in the treatment of primary syphilis.
Dysenteric Amebiasis: Adults:
250 mg 4 times daily for 10-14 days. Children:
30-50 mg/kg/day in divided doses for 10-14 days.
Although optimum dosage and duration of treatment have not been established, dosage of erythromycin utilized in reported clinical studies was 40-50 mg/kg/day, given in divided doses for 5-14 days.
Although optimum doses have not been established, doses utilized in reported clinical data were those recommended (1-4 g erythromycin estolate daily in divided doses).
Conjunctivitis of the Newborn Caused by C. trachomatis:
Oral erythromycin suspension, 50 mg/kg/day in 4 divided doses for at least 2 weeks.
Pneumonia of Infancy Caused by C. trachomatis:
Although the optimum duration of therapy has not been established, the recommended therapy is oral erythromycin suspension, 50 mg/kg/day in 4 divided doses for at least 3 weeks.
Urogenital Infections During Pregnancy Due to C. trachomatis:
Although the optimum dose and duration of therapy have not been established, the suggested treatment is erythromycin, 500 mg orally 4 times a day for at least 7 days. For women who cannot tolerate this regimen, a decreased dose of 250 mg orally 4 times a day should be used for at least 14 days.
For adults with uncomplicated urethral, endocervical or rectal infections caused by C. trachomatis
in whom tetracyclines are contraindicated or not tolerated, 500 mg orally 4 times a day for at least 7 days.